Germinal center-dependent and-independent immune responses of tumor-infiltrating B cells in human cancers  

作　　者：Eve Playoust Romain Remark Eric Vivier Pierre Milpied 

机构地区：[1]Marseille Université,CNRS,INSERM,Centre d’Immunologie de Marseille-Luminy,Marseille,France [2]Innate Pharma,Marseille,France

出　　处：《Cellular & Molecular Immunology》2023年第9期1040-1050,共11页中国免疫学杂志（英文版）

基　　金：We acknowledge all members of the Milpied and Vivier laboratories at CIML for fruitful discussions;EP is supported by a fellowship funded by Innate Pharma and the RHU PIONeeR project(ANR-17-RHUS-00XX-08);This work was supported by grants from ITMO Cancer and the RHU PIONeeR project.

摘　　要：B cells play essential roles in immunity,mainly through the production of high affinity plasma cells(PCs)and memory B(Bmem)cells.The affinity maturation and differentiation of B cells rely on the integration of B-cell receptor(BCR)intrinsic and extrinsic signals provided by antigen binding and the microenvironment,respectively.In recent years,tumor infiltrating B(TIL-B)cells and PCs(TIL-PCs)have been revealed as important players in antitumor responses in human cancers,but their interplay and dynamics remain largely unknown.In lymphoid organs,B-cell responses involve both germinal center(GC)-dependent and GC-independent pathways for Bmem cell and PC production.Affinity maturation of BCR repertoires occurs in GC reactions with specific spatiotemporal dynamics of signal integration by B cells.In general,the reactivation of high-affinity Bmem cells by antigens triggers GC-independent production of large numbers of PC without BCR rediversification.Understanding B-cell dynamics in immune responses requires the integration of multiple tools and readouts such as single-cell phenotyping and RNA-seq,in situ analyses,BCR repertoire analysis,BCR specificity and affinity assays,and functional tests.Here,we review how those tools have recently been applied to study TIL-B cells and TIL-PC in different types of solid tumors.We assessed the published evidence for different models of TIL-B-cell dynamics involving GC-dependent or GC-independent local responses and the resulting production of antigen-specific PCs.Altogether,we highlight the need for more integrative B-cell immunology studies to rationally investigate TIL-B cells as a leverage for antitumor therapies.

关 键 词：ANTIBODY tertiary lymphoid structure plasma cell germinal center cancer 

分 类 号：R730.51[医药卫生—肿瘤]