Lipid scrambling in immunology:why it is important  

作　　者：Ning Wu AndréVeillette 

机构地区：[1]The First Affiliated Hospital of Anhui Medical University,Clinical Immunology Institute,Anhui Medical University,Hefei,Anhui,China [2]Laboratory of Molecular Oncology,Institut de recherches cliniques de Montréal(IRCM),Montréal,QC H2W1R7,Canada [3]Department of Medicine,University of Montréal,Montréal,QC H3T 1J4,Canada [4]Department of Medicine,McGill University,Montréal,QC H3G 1Y6,Canada

出　　处：《Cellular & Molecular Immunology》2023年第9期1081-1083,共3页中国免疫学杂志（英文版）

摘　　要：Asymmetric lipid distribution in the plasma membrane(PM)is one of the fundamental features of living cells.Lipids not only serve as structural components of the biophysical structure of the PM that preserves cell integrity but also participate directly in signaling.Acidic phospholipids(PLs),such as phosphatidylserine(PS),phosphatidylethanolamine(PE),and phosphoinositol(PI),are preferentially located in the inner layer of the PM,creating electrostatic charges for the docking of membrane-associated and cytoplasmic proteins carrying polybasic stretches of amino acids.However,there is emerging evidence that reversible changes in the distribution of these lipids take place in the PM and that these changes are critical for normal cell signaling,functions and homeostasis[1–3].They can also be implicated in the genesis of pathologies.

关 键 词：ELECTROSTATIC REVERSIBLE distribution 

分 类 号：R392[医药卫生—免疫学]