The role of TIA1 and TIAL1 in germinal center B cell function and survival  

作　　者：Yongqiang Wang Jisheng Liu Fangfang Zhou 

机构地区：[1]Department of Otolaryngology Head and Neck Surgery,The First Affiliated Hospital of Soochow University,Suzhou,215123,China [2]Institutes of Biology and Medical Science,Soochow University,Suzhou,215123,China

出　　处：《Cellular & Molecular Immunology》2023年第9期1090-1092,共3页中国免疫学杂志（英文版）

基　　金：The current work was supported by a special program from the Ministry of Science and Technology of China(2022YFA1105200 and 2021YFA1101000);the Chinese National Natural Science Funds(U20A20393,32125016,31925013,31870902 and 32070907);Gusu Innovation Leading Talent Program(ZXL2022505).

摘　　要：B cells are essential components of the adaptive immune system and undergo differentiation and maturation during infection or immune stimulation to produce antibodies that can specifically recognize and bind to antigens.Germinal centers(GCs)are microanatomical sites for the clonal expansion and antibody affinity maturation of B cells.In the dark zone(DZ)of the germinal center,B cells rapidly proliferate,and somatic hypermutation(SHM)of B cell antigen receptors(BCRs)occurs.B cells then migrate to the light zone(LZ).

关 键 词：STIMULATION CENTER MIGRATE 

分 类 号：R392[医药卫生—免疫学]