Structure of human NCC:insights into the inhibition mechanism of thiazides  

作　　者：Livia de Souza Goncalves Pattareeya Yottasan Onur Cil 

机构地区：[1]Department of Pediatrics,University of California,San Francisco,San Francisco,CA,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第8期3549-3550,共2页信号转导与靶向治疗（英文）

基　　金：O.C.is supported by grants from NIH(DK126070 and DK072517);Cystic Fibrosis Foundation.

摘　　要：A recent study published in Nature by Fan et al.1 identified the structure of human NCC alone and in complex with a thiazide diuretic using cryo-electron microscopy.Despite extensive clinical use of NCC inhibitor thiazide diuretics since 1950s,the structure and inhibition mechanisms of NCC have remained elusive,and Fan et al.study is a major step toward better understanding the NCC biology and mechanism of action of thiazide diuretics.Sodium-chloride cotransporter(NCC,also known as SLC12A3)is expressed in the kidney where it facilitates electroneutral NaCl absorption.

关 键 词：AZIDE MECHANISM 

分 类 号：R98[医药卫生—药品]