Cx26 heterozygous mutations:role in hyperacusis and vulnerability to noise  

作　　者：Karen Tawk Mehdi Abouzari 

机构地区：[1]Department of Otolaryngology-Head and Neck Surgery,University of California,Irvine,CA,USA

出　　处：《Signal Transduction and Targeted Therapy》2023年第8期3551-3552,共2页信号转导与靶向治疗(英文)

基　　金：M.A.was supported by the National Center for Research Resources and the National Center for Advancing Translational Sciences,National Institutes of Health,through Grant TL1TR001415.

摘　　要：In a recent study published in Science Advances,Liu et al.demonstrated that heterozygous deletion of connexin 26(Cx26)in mice is not harmless as they lead to hyperacusis-like hearing oversensitivity.The authors also found that children who carry a single-point heterozygous mutation in the gap junction(GJ)gene Cx26(GJB2)are susceptible to noise,which eventually leads to hearing loss(HL).1 HL affects millions of people worldwide and is considered the most prevalent sensory disorder,encompassing a wide range of heterogeneous characteristics.

关 键 词：CX26 noise 

分 类 号：R544.1[医药卫生—心血管疾病]