Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants  

作　　者：Aihua Hao Wenping Song Cheng Li Xiang Zhang Chao Tu Xun Wang Pengfei Wang Yanling Wu Tianlei Ying Lei Sun 

机构地区：[1]MOE/NHC/CAMS Key Laboratory of Medical Molecular Virology,Shanghai Institute of Infectious Disease and Biosecurity,Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection,Shanghai Engineering Research Center for Synthetic Immunology,Shanghai Fifth People’s Hospital,Institutes of Biomedical Sciences,School of Basic Medical Sciences,Fudan University,Shanghai,China [2]Biomissile Corporation,Shanghai,China [3]State Key Laboratory of Genetic Engineering,Shanghai Institute of Infectious Disease and Biosecurity,School of Life Sciences,Fudan University,Shanghai,China

出　　处：《Signal Transduction and Targeted Therapy》2023年第8期3567-3569,共3页信号转导与靶向治疗（英文）

基　　金：This work was supported by grants from the Ministry of Science and Technology of China(2019YFA0904400 to TY,2021YFC2302500 to LS);National Natural Science Foundation of China(32270984,32270142);Shanghai Municipal Science and Technology Major Project(ZD2021CY001);by R&D Program of Guangzhou Laboratory(SRPG22-003 to LS).

摘　　要：Dear Editor,In recent months,additional Omicron variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),including the BA.5 sublineage BF.7 and BQ.1.1 and the BA.2 linage recombination XBB,XBB.1.5 and XBB.1.16,have emerged following the BA.2 and BA.5 subvariants.Remarkably,BQ.1.1 and XBB showed substantial neutralization escape as compared with the previous variants,and have gradually become the dominant variants worldwide.1 These facts emphasize the urgency of identifying highly conserved SARS-CoV-2 epitopes,which would be essential for the design of universal vaccines and broadly neutralizing antibodies.

关 键 词：ACUTE VARIANTS CONSERVED 

分 类 号：R392[医药卫生—免疫学]