西藏地区0~6岁儿童乙型肝炎表面抗原携带情况  

An investigation of Hepatitis B surface antigen carriers in children aged 0~6 years in Tibet region

作　　者：温青萍 张艳 钱花 石荔[1] WEN Qing-ping;ZHANG Yan;QIAN Hua;SHI Li(Department of Infection,People’s Hospital of Tibet Autonomous Region,Lhasa 850000,China)

机构地区：[1]西藏自治区人民医院感染科,拉萨850000

出　　处：《肝脏》2023年第9期1050-1052,共3页Chinese Hepatology

基　　金：西藏自治区人民医院“应用基础研究”项目(XZQYY2020027)。

摘　　要：目的调查分析西藏地区0~6岁儿童HBsAg携带情况。方法2021年1月至2022年7月随机抽取西藏地区6岁以下儿童32927名。采用胶体金法检测儿童及其母亲HBsAg。结果儿童血清HBsAg阳性携带者有1313名(3.99%),母亲血清HBsAg阳性携带者有2626名(7.98%)。男性儿童和女性儿童HBsAg阳性率分别为4.10%和3.86%,差异无统计学意义。不同年龄儿童血清HBsAg阳性率不同,2~3周岁儿童血清HBsAg阳性率最低,3周岁以下儿童随着年龄降低血清HBsAg阳性率逐渐升高,3周岁以上儿童随着年龄增长血清HBsAg阳性率逐渐升高。未接种乙型肝炎疫苗儿童血清HBsAg阳性率为6.27%,显著高于接种乙型肝炎疫苗儿童的3.81%。母亲血清HBsAg阳性儿童血清HBsAg阳性率为36.97%,显著高于母亲血清HBsAg阴性儿童为1.13%。结论西藏地区0~6岁儿童HBsAg阳性率整体偏高,乙型肝炎计划免疫工作仍需加强,未接种乙型肝炎疫苗的儿童以及母亲血清HBsAg阳性儿童为重点人群。Objective To investigate the situation of HBsAg carriers in children aged 0~6 years in Tibet,and to provide reference for hepatitis B vaccination,health education and mother-to-child transmission in children in Tibet.Methods A total of 32,927 children under 6 years of age in Tibet were included in this study by random sampling method from January 2021 to July 2022.Venous blood samples of the children and their mothers were collected for HBsAg screening by Colloidal gold test method.Results 1313(3.99%)children and 2626(7.98%)mothers were HBsAg positive carriers in this group.The positive rate of HBsAg in male and female children was 4.07%and 3.86%,respectively,with no significant difference.The positive rate of HBsAg in children of different ages was different.The positive rate of HBsAg in children of 2~3 years old was the lowest.The positive rate of HBsAg in children of less than 3 years old gradually increased with the decreasing of age,and the positive rate of HBsAg in children of over 3 years old gradually increased with the increasing of age.The positive rate of HBsAg in children without hepatitis B vaccination(6.27%)was significantly higher than that in children with hepatitis B vaccination(3.81%).The positive rate of HBsAg in children with HBsAg positive mothers(36.97%)was significantly higher than that in children with HBsAg negative mothers(1.13%).Conclusion The positive rate of HBsAg in children aged 0 to 6 years is generally high in Tibet,and the immunization plan of hepatitis B needs to be strengthened,especially for the children who haven′t received hepatitis B vaccine and the children whose mothers are HBsAg positive.

关 键 词：儿童 乙型肝炎 乙型肝炎表面抗原 西藏 

分 类 号：R725.1[医药卫生—儿科]