微小RNA在脓毒症所致急性肾损伤中的应用  

MicroRNA in acute kidney injury due to sepsis

作　　者：董虹杏 武卫东[1] Dong Hongxing;Wu Weidong(Department of Critical Care Medicine,Third Hospital of Shanxi Medical University,Shanxi Bethune Hospital,Taiyuan,030032 China)

机构地区：[1]山西医科大学第三医院,山西白求恩医院重症医学科,太原030032

出　　处：《中国综合临床》2023年第5期385-388,共4页Clinical Medicine of China

摘　　要：脓毒症是指机体对感染免疫反应失调造成的以器官功能障碍为特征的危及生命的临床综合征,是危重症患者发生急性肾损伤(acute kidney injury,AKI)的首要病因。脓毒症所致急性肾损伤(sepsis induced AKI,S-AKI)是临床常见的危重症,病死率高,且与危重症患者的临床结局密切相关。目前临床上AKI诊断仍是以血清肌酐、尿量等传统指标为标准,但其易受到年龄、性别、药物等因素的干扰,无法准确、敏感地反映出患者肾脏受损情况,使部分AKI患者失去最佳的治疗时机。所以临床上急需一些敏感度强、特异性高的生物标志物来帮助AKI的诊断,以便积极采取治疗措施,缓解AKI预后。大量研究表明,微小RNA(miRNAs)参与S-AKI的发生发展,因此,miRNAs不仅可成为S-AKI诊断标志物,还对S-AKI的治疗和预后的判断具有重要的潜在价值。现就miRNA对S-AKI诊断、预后和治疗的潜在价值进行综述。Sepsis is a life-threatening clinical syndrome characterized by organ dysfunction caused by dysregulation of the body's immune response to infection,and is the primary cause of acute kidney injury in critically ill patients.Sepsis induced AKI(S-AKI)is a common clinical critical illness with a high mortality rate and is closely associated with the clinical outcome of critically ill patients.At present,the clinical diagnosis of AKI is still based on the traditional indicators such as serum creatinine and urine output,but it is easily interfered by age,gender,drugs and other factors,and cannot accurately and sensitively reflect the renal damage of patients,so that some AKI patients lose the best time for treatment.Therefore,some biomarkers with strong sensitivity and high specificity are urgently needed in the clinic to help the diagnosis of AKI,so as to take active therapeutic measures to alleviate the prognosis of AKI.Numerous studies have shown that microRNAs(miRNAs)are involved in the development of S-AKI.Therefore,miRNAs can not only be early diagnostic markers of S-AKI,but also have important potential value for the treatment and prognosis of S-AKI.In this paper,we review the potential value of miRNA for the diagnosis,prognosis and treatment of S-AKI.

关 键 词：脓毒症 急性肾损伤 微小RNA 诊断 预后 治疗 

分 类 号：R459.7[医药卫生—急诊医学] R692[医药卫生—治疗学]