丹黄祛瘀胶囊联合米非司酮片治疗子宫腺肌病临床研究  

Clinical Study on Danhuang Quyu Capsules Combined with Mifepristone Tablets for Adenomyosis

作　　者：马雪莲[1] MA Xuelian(Anji County Third People's Hospital,Anji Zhejiang 313300,China)

机构地区：[1]安吉县第三人民医院,浙江安吉313300

出　　处：《新中医》2023年第18期82-86,共5页New Chinese Medicine

摘　　要：目的:观察丹黄祛瘀胶囊联合米非司酮片治疗子宫腺肌病的疗效。方法:选取112例气虚血瘀、痰湿凝滞型子宫腺肌病患者,依照随机数字表法分成常规组和治疗组各56例。2组均予米非司酮片治疗,治疗组加服丹黄祛瘀胶囊治疗。4周为1个疗程,2组均持续治疗3个疗程。比较2组的临床疗效,治疗前后检测子宫体积、子宫动脉血流阻力指数(RI),评定痛经积分、月经量积分,检测血清糖类抗原125 (CA125)、促黄体生成素(LH)、促卵泡生成素(FSH)含量。记录不良反应发生情况。结果:治疗后,治疗组总有效率94.64%,常规组总有效率82.14%,2组比较,差异有统计学意义(P<0.05)。2组子宫体积均较治疗前缩小,子宫动脉RI值均低于治疗前,差异均有统计学意义(P<0.05)。治疗组子宫体积小于常规组,子宫动脉RI值低于常规组,差异均有统计学意义(P<0.05)。2组痛经积分、月经量积分均低于治疗前(P<0.05)。治疗组痛经积分、月经量积分均低于常规组(P<0.05)。2组血清CA125、LH、FSH含量均低于治疗前(P<0.05)。治疗组血清CA125、LH、FSH含量均低于常规组(P<0.05)。结论:采用丹黄袪瘀胶囊联合米非司酮片治疗气虚血瘀、痰湿凝滞型子宫肌腺病,可有效减轻痛经,恢复正常月经量,提高卵巢功能,安全性好。Objective:To observe the curative effect of Danhuang Quyu Capsules combined with Mifepristone Tablets for adenomyosis.Methods:A total of 112 cases of patients with adenomyosis of qi deficiency and blood stasis complicated with phlegm-damp coagulation and stagnation type were selected and divided into the routine group and the treatment group according to the random number table method,with 56 cases in each group.Both groups were treated with Mifepristone Tablets,and the treatment group was additionally treated with Danhuang Quyu Capsules.Both groups were treated for 3 courses,with4 weeks being a course.The clinical effects were compared between the two groups.Before and after treatment,uterine volume and resistance index(RI) of uterine arterial blood flow were detected;the scores of dysmenorrhea and menstrual volume were evaluated;the levels of carbohydrate antigen125(CA125),luteinizing hormone(LH),and follicle-stimulating hormone(FSH) in serum were detected.The incidence of adverse reactions was recorded.Results:After treatment,the total effective rate was94.64% in the treatment group and 82.14% in the routine group,the difference being significant(P<0.05).The uterine volumes in the two groups were decreased when compared with those before treatment,and the RI values in uterine artery were lower than those before treatment,differences being significant(P<0.05).The uterine volume in the treatment group was smaller than that in the routine group,and the RI value in uterine artery was lower than that in the control group,differences being significant(P<0.05).The scores of dysmenorrhea and menstrual volume in the two groups were lower than those before treatment(P<0.05),and the scores of dysmenorrhea and menstrual volume in the treatment group were lower than those in the routine group(P<0.05).The contents of CA125,LH,and FSH in serum in the two groups were lower than those before treatment(P<0.05),and the contents of CA125,LH,and FSH in serum in the treatment group were lower than those in the routine group(P<0.05)

关 键 词：子宫腺肌病 气虚血瘀证 痰湿凝滞证 丹黄祛瘀胶囊 黄体生成素 卵泡刺激素 

分 类 号：R711.71[医药卫生—妇产科学]