固表止汗方洗浴联合维生素D滴剂治疗维生素D缺乏性佝偻病临床研究  

Clinical Study on Bath with Gubiao Zhihan Prescription Combined with Vitamin D Drops for Vitamin D-Deficient Rickets

作　　者：陈虹余 李正琳 韦小霞 CHEN Hongyu;LI Zhenglin;WEI Xiaoxia(Guangxi International Zhuang Medicine Hospital,Nanning Guangxi 530200,China)

机构地区：[1]广西国际壮医医院,广西南宁530200

出　　处：《新中医》2023年第18期93-97,共5页New Chinese Medicine

基　　金：广西壮族自治区中医药管理局2020年自筹经费科研课题(GZZC2020165)。

摘　　要：目的:观察固表止汗方洗浴联合维生素D滴剂治疗肺脾气虚型维生素D缺乏性佝偻病(VDDR)的临床疗效。方法:选取60例肺脾气虚型VDDR患儿,按随机数字表法分为对照组与观察组各30例。研究过程中,对照组剔除4例,观察组剔除5例,最终纳入研究对照组26例,观察组25例。对照组给予维生素D滴剂治疗,观察组在对照组基础上给予固表止汗方洗浴治疗,2组均治疗1个月。比较2组临床疗效,血钙、血磷、25-羟基维生素D[25 (OH) VD]、碱性磷酸酶(ALP)水平与中医证候积分,观察2组治疗前后汗出情况。结果:治疗后,观察组临床疗效总有效率92.00%,高于对照组65.38%(P<0.05)。2组中医证候积分均较治疗前降低(P<0.05),观察组中医证候积分低于对照组(P<0.05)。2组血钙、25 (OH) VD水平均较治疗前升高(P<0.05),ALP水平均较治疗前降低(P<0.05)。2组血磷水平与治疗前比较,差异均无统计学意义(P>0.05)。治疗后,观察组ALP水平低于对照组(P<0.05),25 (OH) VD水平高于对照组(P<0.05),2组血钙、血磷水平比较,差异均无统计学意义(P>0.05)。观察组对汗出的改善效果优于对照组(P<0.05)。结论:固表止汗方洗浴联合维生素D滴剂治疗肺脾气虚型VDDR的临床疗效优于单独使用维生素D滴剂治疗,可有效缓解患儿的临床症状,降低ALP水平,提高25 (OH) VD水平。Objective:To observe the clinical effect of the therapy of bath with Gubiao Zhihan Prescription combined with Vitamin D Drops on vitamin D-deficient rickets(VDDR) of lung-spleen qi deficiency type.Methods:A total of 60 VDDR children of lung-spleen qi deficiency type were selected and divided into the control group and the observation group according to the random number table method,with 30 cases in each group.During the study,4 cases in the control group and 5 cases in the observation group were dropped off.Finally,26 and 25 cases were included into the control group and the observation group.The control group was given Vitamin D Drops for treatment,and the observation group was additionally treated with bath with Gubiao Zhihan Prescription based on the treatment of the control group.Both groups were treated for 1 month.The clinical effects,levels of blood calcium,serum phosphate,25-hydroxyl vitamin D [25(OH) VD] and alkaline phosphatase(ALP),and traditional Chinese medicine(TCM)syndrome scores were compared between the two groups.The sweating in both groups were observed before and after treatment.Results:After treatment,the total clinical effective rate was 92.00% in the observation group,higher than that of 65.38% in the control group(P<0.05).The TCM syndrome scores in the two groups were decreased when compared with those before treatment(P<0.05),and the TCM syndrome score in the observation group was lower than that in the control group(P<0.05).The levels of blood calcium and 25(OH) VD in both groups were increased when compared with those before treatment(P<0.05),and the levels of ALP in both groups were decreased(P<0.05).There was no significant difference being found in the comparison of levels of serum phosphate in both groups with those before treatment(P>0.05).After treatment,the ALP level in the observation group was lower than that in the control group(P<0.05),the 25(OH) VD level was higher than that in the control group(P<0.05).There was no significant difference being found in the comparisons of l

关 键 词：维生素D缺乏性佝偻病 肺脾气虚型 固表止汗方 洗浴 维生素D滴剂 碱性磷酸酶 25-羟基维生素D 

分 类 号：R723.2[医药卫生—儿科]