基于数据挖掘研究国医大师周仲瑛治疗结缔组织病合并间质性肺病证治规律  

Study on Treatment Rules of Traditional Chinese Medicine Master ZHOU Zhongying for Connective Tissue Disease Complicated with Interstitial Lung Disease Based on Data Mining

作　　者：李玲[1] 陆燕[2] 叶放[3] 周学平[3] LI Ling;LU Yan;YE Fang;ZHOU Xueping(Taizhou Hospital Affiliated to Nanjing University of Chinese Medicine,Taizhou Jiangsu 225300,China;Jiangsu Province Hospital of Chinese Medicine,Nanjing Jiangsu 210029,China;ZHOU Zhongying Inheritance Research Studio of the First Clinical Medical College of Nanjing University of Chinese Medicine,Nanjing Jiangsu 210029,China)

机构地区：[1]南京中医药大学泰州附属医院,江苏泰州225300 [2]江苏省中医院,江苏南京210029 [3]南京中医药大学第一临床医学院国医大师周仲瑛传承研究工作室,江苏南京210029

出　　处：《新中医》2023年第18期187-192,共6页New Chinese Medicine

基　　金：国家中医药管理局“国医大师周仲瑛学术经验传承研究室”建设项目(201059);江苏省社会发展重点研发计划(BE2019723);江苏省中医药科技发展计划(QN202119);江苏省泰州市科技支撑计划(社会发展)项目指令性计划(TS201809)。

摘　　要：目的:基于数据挖掘研究国医大师周仲瑛教授辨治结缔组织病合并间质性肺病(CTD-ILD)的诊疗规律及用药经验。方法:收集周仲瑛教授诊治CTD-ILD医案,运用频数分析、关联规则、聚类分析等方法进行数据挖掘。结果:共筛选出128份医案,含193味中药。涉及病种有6种,病机排名前5位的是气阴两伤、痰瘀阻肺、肺虚热郁、肝肾亏虚、脾虚肺弱;使用中药排名前5位的是南沙参、北沙参、麦冬、紫苏子、太子参;关联规则分析显示,置信度、支持度均较高的为气阴两伤-南沙参、北沙参、麦冬、太子参、黄芪;痰瘀阻肺-紫苏子、桃仁、鱼腥草、炙僵蚕、泽漆、法半夏、老鹳草;高频药物聚类分析得到4个方剂组,以益气养阴、祛痰化瘀、补肺健脾、补益肝肾、祛风除湿为主。结论:国医大师周仲瑛教授辨治CTD-ILD主张病证结合,在疾病发展动态过程中,基于复合病机,通润为要,复法制方。Objective:To study the diagnosis and treatment rules as well as medication experience of traditional Chinese medicine(TCM) master ZHOU Zhongying for connective tissue disease complicated with interstitial lung disease(CTD-ILD) based on data mining.Methods:The medical records of Professor ZHOU Zhongying treating CTD-ILD were collected,and the data were mined by means of frequency analysis,association rules,and cluster analysis.Results:A total of 128 cases of medical records were selected,containing 193 Chinese medicinals.There were six kinds of diseases involved,and the top five pathogenesis were damage to both qi and yin,phlegm-stasis obstructing the lung,lung deficiency and heat constraint,liver-kidney deficiency,and spleen deficiency and lung weakness.The top five Chinese medicinals used were Adenophorae Radix,Glehniae Radix,Ophiopogonis Radix,Perillae Fructus,and Pseudostellariae Radix;association rule analysis showed that the Chinese medicinals with the higher confidence and support were Adenophorae Radix,Glehniae Radix,Ophiopogonis Radix,Pseudostellariae Radix,and Astragali Radix for damage to both qi and yin;Perillae Fructus,Persicae Semen,Houttuyniae Herba,Batryticatus Bombyx,Herba Euphoribiae Helioscopiae,Rhizoma Pinelliae Praeparatum,and Herba Erodii Stephaniani for phlegm-stasis obstructing the lung;four prescription groups were obtained by cluster analysis on high-frequency used medicinals,which mainly used for boosting qi and nourishing yin,dispelling phlegm and dissolving stasis,supplementing lung and fortifying the spleen,supplementing and boosting liver and kidney,and dispelling wind and eliminating dampness.Conclusion:Professor ZHOU Zhongying,the TCM master,advocated the combination of disease and syndrome in treating CTD-ILD,and making composite prescriptions with regulating and nourishing being the key based on the compound pathogenesis in the dynamic process of disease development.

关 键 词：结缔组织病合并间质性肺病 数据挖掘 益气养阴 祛痰化瘀 国医大师 周仲瑛 

分 类 号：R593.2[医药卫生—内科学]