右美托咪定联合舒芬太尼及地佐辛对腹腔镜胆囊切除术围术期的镇痛效果及安全性  

The Study on Analgisic Effect and Its Pharmacovigilance of Dexmedetomidine in Combination with Sufentanil and Dizocin in Perioperative Laparoscopic Cholecystectomy

作　　者：林浩[1] 于淑侠[1] 陈一林 张绍刚[1] Lin Hao;Yu Shuxia;Chen Yilin;Zhang Shaogang(Department of Anesthesiology,Nanjing Hospital of Integrated Chinese and Western Medicine,Nanjing 210014,Jiangsu Province,China)

机构地区：[1]南京市中西医结合医院麻醉科,江苏南京210014

出　　处：《中外医药研究》2023年第16期33-35,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨右美托咪定联合舒芬太尼及地佐辛用于腹腔镜胆囊切除术(LC)围术期镇痛的效果及安全性。方法:选取2021年1月—2022年12月南京市中西医结合医院收治的拟行LC治疗的胆结石患者92例为研究对象,采用抽签法分为观察组和对照组,各46例。两组均常规麻醉后进行腹腔镜胆囊切除术,对照组采用舒芬太尼、地佐辛进行静脉自控镇痛,观察组采用右美托咪定联合舒芬太尼、地佐辛进行静脉自控镇痛。比较两组患者术后自控镇痛使用情况、术后疼痛程度、不良反应发生率。结果:观察组自控镇痛按压次数和镇痛药物总用量均优于对照组,差异有统计学意义(P<0.001);观察组术后6、12、24、48h视觉模拟评分法评分均低于对照组,差异有统计学意义(P<0.001);观察组不良反应发生率低于对照组,差异有统计学意义(P=0.048)。结论:LC患者采用右美托咪定联合舒芬太尼、地佐辛进行围术期镇痛的效果较好,可改善患者术后自控镇痛使用情况及疼痛程度,且安全性良好。Objective:To investigate the efficacy and safety of dexmedetomidine combined with sufentanil and dizocin for periop⁃erative pain management in laparoscopic cholecystectomy(LC).Methods:92 patients with gallstones to be treated with LC admit⁃ted to Nanjing Hospital of Integrated Chinese and Western Medicine from January 2021 to December 2022 were selected as the study subjects,and were divided into the observation group and the control according to the lottery method,each group with 46 cases.Both groups underwent laparoscopic cholecystectomy after conventional anesthesia,and the control group used sufentanil and dizocin for patient-controlled intravenous analgesia pump,while the observation group used dexmedetomidine combined with sufentanil and dizocin through Patient-controlled intravenous analgesia Pump.Compare the dosage of analgesia pumps,postopera⁃tive pain level,and the incidence of adverse reactions in the two groups.Results:The application frequency of self-controlled an⁃algesic and the total dosage of analgesic drugs in the observation group were better than those in the control group,and the differ⁃ence was statistically significant(P<0.001);the scores of visual analog scoring method in the observation group were lower than those in the control group respectively 6,12,24 and 48 hours after the surgery,and the difference was statistically significant(P<0.001);and the incidence rate of adverse reactions was lower than that in the control group,and the difference was statistically significant(P=0.048).Conclusion:The pain management through dexmedetomidine combined with sufentanil and diazoxide for pa⁃tients with LC is more effective,reduce the application frequency of patient-controlled analgesic pump and the degree of pain in patients,and has a good safety profile.

关 键 词：胆结石 腹腔镜胆囊切除术 右美托咪定 疼痛 不良反应 

分 类 号：R61[医药卫生—外科学]