BF_(3)·OEt_(2)作为催化剂与合成子在有机合成中的应用进展  

Application of BF_(3)·OEt_(2) in Organic Synthesis as a Catalyst or Synthon

作　　者：陈祖佳 宇世伟 周永军 李焕清 邱琪雯 李妙欣 汪朝阳[1] Chen Zujia;Yu Shiwei;Zhou Yongjun;Li Huanqing;Qiu Qiwen;Li Miaoxin;Wang Zhaoyang(School of Chemistry,South China Normal University,Key Laboratory of Theoretical Chemistry of Environment,Ministry of Education,Guangzhou Key Laboratory of Analytical Chemistry for Biomedicine,Key Laboratory for Process Control and Quality Evaluation of Chiral Pharmaceuticals,Guangdong Medical Products Administration,Guangzhou 510006)

机构地区：[1]华南师范大学化学学院、教育部环境理论化学重点实验室、广州市生物医学分析化学重点实验室、广东省药品监督管理局手性药物过程控制与质量评价重点实验室,广州510006

出　　处：《有机化学》2023年第9期3107-3118,共12页Chinese Journal of Organic Chemistry

基　　金：广东省基础与应用基础研究基金(2021A1515012342)。

摘　　要：BF_(3)·OEt_(2)作为一个催化能力非常优秀的典型路易斯酸催化剂,在催化偶联、环化和重排等方面发挥着重要的作用,广泛应用于天然产物、医药分子和其他功能分子的合成中.有趣的是,当有水存在时,BF_(3)·OEt_(2)能与水结合成为布朗斯特酸,也能够促进偶联、加成等反应的进行.同时,BF_(3)·OEt_(2)不仅仅局限于催化反应,亦可作为合成子,较温和地构建含B原子、F原子以及BF2结构分子的化合物,在催化配体、荧光分子领域等有着重要的作用.以BF_(3)·OEt_(2)的催化反应类型和其作为合成子的应用为依据,综述了近年来其在有机合成中的应用.展望未来,人们将会对其性能与应用有更多的了解,发展出更多催化体系和合成子应用.BF_(3)·OEt_(2),as a typical Lewis acid catalyst with excellent catalytic capacity,plays an important role in many reactions,such as coupling,cyclization and rearrangement,and it is widely used in the synthesis of natural products,pharmaceutical molecules and other functional molecules.Interestingly,in the presence of water,BF_(3)·OEt_(2)can be combined with water to form Bronsted acid,which can also promote the coupling,addition,and other reactions.At the same time,BF_(3)·OEt_(2)is not only limited to be a catalyst,but also can be used as a synthon to mildly construct compounds containing B,F and BF_(2)structure molecules,which plays an important role in the field of catalytic ligand and fluorescence molecules.Based on various catalytic reaction types using BF_(3)·OEt_(2)and its different applications as a synthon,the research progress on the application of BF_(3)·OEt_(2)in organic synthesis in recent years is reviewed.Looking forward to the future,with the in-depth study of BF_(3)·OEt_(2),there will be more understanding of its performance and application,it is possible to develop more surprising catalytic systems and synthetic applications.

关 键 词：BF_(3)·OEt_(2) 路易斯酸 偶联反应 加成反应 二氟硼化合物 

分 类 号：O621.3[理学—有机化学] O643.36[理学—化学]