3-(三氟甲基)吡唑类化合物的合成  

Synthesis of 3-Trifluoromethylpyrazole Derivatives

作　　者：马虎 黄丹凤[1] 王克虎[1] 唐朵朵 冯杨 任园园 王君娇 胡雨来[1] Ma Hu;Huang Danfeng;Wang Kehu;Tang Duoduo;Feng Yang;Reng Yuanyuan;Wang Junjiao;Hu Yulai(College of Chemistry and Chemical Engineering,Northwest Normal University,Lanzhou 730070)

机构地区：[1]西北师范大学化学化工学院,兰州730070

出　　处：《有机化学》2023年第9期3257-3267,共11页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(22061037);国家自然科学基金(21861033);上海恩氟佳科技有限公司资助项目。

摘　　要：探索了三氟甲基溴代腙与炔酮、炔酯和炔酰胺的[3+2]环加成反应, 以中等至优异的产率得到了一系列3-(三氟甲基)吡唑类化合物. 该方法具有区域选择性高、官能团兼容性强、操作简单和反应条件温和等特点, 为合成3-(三氟甲基)吡唑类化合物提供了一种高效的新方法.The [3+2] cycloaddition reactions of trifluoroacetohydrazonoyl bromides with ynones, alkynoates and aynamides have been developed, and a series of 3-trifluoromethylpyrazole derivatives were obtained in medium to excellent yields. The noble features of this protocol include excellent regioselectivity, good functional group tolerance, mild reaction conditions and simple operation. It provides an efficient and practical method for the synthesis of 3-trifluoromethylpyrazoles.

关 键 词：三氟甲基 吡唑 腈亚胺 三氟甲基溴代腙 [3+2]环加成 

分 类 号：O626[理学—有机化学]