低共熔溶剂1,3-二甲基脲/L-(+)-酒石酸中(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成  

Deep Eutectic Solvent of 1,3-Dimethylurea/L-(+)-Tartaric Acid for the Green Synthesis of (E)-2-Styrylquinoline-3-carboxylic Acid Derivatives

作　　者：李阳[1] 袁锦鼎 赵頔 Li Yang;Yuan Jinding;Zhao Di(College of Chemistry and Chemical Engineering,Bohai University,Jinzhou,Liaoning 121000)

机构地区：[1]渤海大学化学与材料工程学院,辽宁锦州121000

出　　处：《有机化学》2023年第9期3268-3276,共9页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(21402011);辽宁省博士启动基金(2019-BS-004);辽宁省教育厅科学研究基金(LQ2019006)。

摘　　要：利用环境友好且无毒无害的1,3-二甲基脲(DMU)/L-(+)-酒石酸(LTA) (n∶n=7∶3)形成的低共熔溶剂(DES)作为反应介质和催化剂使2-甲基喹啉-3-羧酸与芳醛直接进行有效的乙烯化反应, 成功实现了(E)-2-苯乙烯基喹啉-3-羧酸类衍生物的绿色合成. 所开发的合成方法具有温和且环境友好的反应条件, 实验操作简便, 后处理简单和收率高等优点, 具有很好的实际应用价值.A green, efficient and catalyst-free synthesis of (E)-2-styrylquinoline-3-carboxylic acid derivatives via direct olefination of 2-methylquinoline-3-carboxylic acid with aromatic aldehydes has been accomplished successfully by using environmentally benign and non-toxic deep eutectic solvent (DES) of 1,3-dimethylurea (DMU)/L-(+)-tartaric acid (LTA) (n∶n=7∶3) as a dual catalyst and reaction medium. The synthetic strategy has the attractive features such as mild and environmentally benign reaction conditions, experimental simplicity, easy work-up procedure and good yields, which would contribute to the usefulness of this method.

关 键 词：绿色合成 2-苯乙烯基喹啉 1 3-二甲基脲 L-(+)-酒石酸 低共熔溶剂 

分 类 号：O626[理学—有机化学]