禾谷镰刀菌中一个新的聚酮类化合物  

A New Polyketide from Fusarium graminearum

作　　者：丁卫忠 张炳文 薛彦青 林雨琦 汤志军 王婧 杨文超 王晓峰 刘文 Ding Weizhong;Zhang Bingwen;Xue Yanqing;Lin Yuqi;Tang Zhijun;Wang Jing;Yang Wenchao;Wang Xiaofeng;Liu Wen(Department of Chemistry,University of Science and Technology of China,Hefei 230026;Key Laboratory of Pesticide&Chemical Biology,Ministry of Education,College of Chemistry,Central China Normal University,Wuhan 430079;School of Chemistry and Materials Science,Hangzhou Institute for Advanced Study,University of Chinese Academy of Sciences,Hangzhou 310024;State Key Laboratory of Bioorganic and Natural Products Chemistry,Shanghai Institute of Organic Chemistry,University of Chinese Academy of Sciences,Shanghai 200032)

机构地区：[1]中国科学技术大学化学系,合肥230026 [2]华中师范大学化学学院、农药与化学生物学教育部重点实验室,武汉430079 [3]国科大杭州高等研究院、化学与材料科学学院,杭州310024 [4]中国科学院上海有机化学研究所、生命有机化学国家重点实验室,上海200032

出　　处：《有机化学》2023年第9期3319-3322,共4页Chinese Journal of Organic Chemistry

基　　金：科技部重大专项(2022YFC2303100);国家自然科学基金(22193070);国家自然科学基金(32030002);浙江省博士后科研项目择优资助项目。

摘　　要：镰刀菌属真菌能产生结构多样的活性天然产物. 对该属真菌Fusarium graminearum培养物的萃取物进行化学成分研究, 从中分离得到一个新的聚酮类化合物, 并将其命名为fusarane A (1). 综合运用高分辨质谱、一维、二维的核磁共振波谱和X射线单晶衍射方法对化合物1的结构进行了鉴定. 从结构上看, 化合物1具有少见的共轭多烯片段, 并且其所有的双键构型都为E构型. 此外, 生物活性测试结果表明, 在联用具有增强抗生素活性的佐剂双硫仑(10 μg/mL)时, 化合物1对金黄色葡萄球菌S. aureus ATCC 29213有潜在的抗菌活性, 最小抑菌浓度为32 μg/mL.The fungus Fusarium species is well known for producing bioactive natural products with diverse structures.A chemical investigation on the cultures extract of the Fusarium graminearum led to the isolation of one new polyketide,fusarane A(1).Its structure was elucidated on the basis of extensive HRESIMS,1D and 2D-NMR spectra data analysis,and single-crystal X-ray diffraction.Structurally,compound 1 has a rare conjugated polyene moiety in which configurations of all double bonds were determined to be E.Furthermore,1 showed potent inhibitory activity against S.aureus ATCC 29213 with the MIC value of 32μg/mL when assayed in combination with disulfram(10μg/mL),an established antibiotic adjuvant that augmented the activity of antibiotics.

关 键 词：禾谷镰刀菌 天然产物 聚酮 抗菌活性 

分 类 号：O632.4[理学—高分子化学]