中国血吸虫病患者共病抑郁和焦虑及心理干预效果的meta分析  

Prevalence of comorbid depression and anxiety and effect of psychological interventions among schistosomiasis patients in China:a meta-analysis

作　　者：王媺媞 金贵香 程影 郑金鑫 田利光 张顺先 洪武[1,5] WANG Meiti;JIN Guixiang;CHENG Ying;ZHENG Jinxin;TIAN Liguang;ZHANG Shunxian;HONG Wu(The Sixth Department of Clinical Medicine,Shanghai Mental Health Center Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 201100,China;Yangpu District Mental Health Center,Shanghai Municipality,China;National Insti-tute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),Na-tional Health Commission Key Laboratory of Parasite and Vector Biology,WHO Collaborating Centre for Tropical Diseases,Nation-al Center for International Research on Tropical Diseases,School of Global Health,Shanghai Jiaotong University School of Medi-cine and Chinese Center for Tropical Diseases Research,Shanghai 200025,China;Institute of Respiratory Diseases,Longhua Hos-pital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Shanghai Key Laboratory of Psychotic Disorders,Shanghai 201100,China)

机构地区：[1]上海交通大学医学院附属精神卫生中心临床六科,上海201100 [2]上海市杨浦区精神卫生中心 [3]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、WHO热带病合作中心、国家级热带病国际联合研究中心、上海交通大学医学院-国家热带病研究中心全球健康学院 [4]上海中医药大学附属龙华医院呼吸疾病研究所 [5]上海市重性精神病重点实验室

出　　处：《中国血吸虫病防治杂志》2023年第4期340-348,共9页Chinese Journal of Schistosomiasis Control

基　　金：上海市“科技创新行动计划”医学创新研究专项(21Y11905600);上海市“科技创新行动计划”自然科学基金(21ZR1455100);上海市精神卫生中心院级课题(2021-YJ02)。

摘　　要：目的了解中国血吸虫病患者共病抑郁和焦虑患病率以及使用心理干预治疗的效果,为改善患者心理健康状况提供依据。方法在中国期刊全文数据库(CNKI)、万方数据资源系统、PubMed、Web of Science、Embase中,检索公开发表的有关中国血吸虫病患者共病焦虑、抑郁,以及心理干预治疗的文献。对文献进行筛选后,提取共病率、心理治疗方法、治疗前后抑郁自评量表(self-rating depression scale,SDS)和焦虑自评量表(self-rating anxiety scale,SAS)评分等数据,采用meta分析对中国血吸虫病患者抑郁、焦虑共病率进行分析,并评价心理干预方法治疗患者焦虑、抑郁的效果。结果共检索到231篇文献,最终筛选出符合纳入和排除标准的14篇文献,包括2篇英文文献、12篇中文文献。Meta分析结果显示,中国血吸虫病患者抑郁共病率为61%[95%可信区间(confidence interval,CI):(48%,72%)],焦虑共病率为64%[95%CI:(42%,81%)]。经心理干预治疗后,血吸虫病患者SDS量表评分[1.45,95%CI:(1.30,1.60)]、SAS量表评分[2.21,95%CI:(2.05,2.38)]均较治疗前降低,病例组SDS量表评分[-0.47,95%CI:(-0.69,-0.25)]、SAS量表评分[-1.30,95%CI:(-1.52,-1.09)]均低于对照组。结论中国血吸虫病患者共病焦虑及抑郁情绪问题较普遍,临床常用心理干预方法有助于改善血吸虫病患者抑郁和焦虑症状。Objective To investigate the prevalence of comorbid depression and anxiety and to evaluate the effect of psychological interventions among schistosomiasis patients in China,so as to provide insights into improvements of psychological health among schistosomiasis patients.Methods Publications pertaining to comorbid depression and anxiety and psychological interventions among Chinese schistosomiasis patients were retrieved in electronic databases,including CNKI,Wanfang Data,PubMed,Web of Science,and Embase.The prevalence of comorbidity,psychological interventions,and scores for the Self-Rating Depression Scale(SDS) and Self-Rating Anxiety Scale(SAS) before and after psychological interventions among Chinese schistosomiasis patients were extracted.The prevalence of comorbid depression and anxiety was investigated among Chinese schistosomiasis patients using a meta-analysis,and the effect of psychological interventions for depression and anxiety was evaluated.Results A total of 231 publications were retrieved,and 14 publications that met the inclusion and exclusion criteria were included in the final analysis,including 2 English publications and 12 Chinese publications.Meta-analysis showed that the prevalence rates of comorbid depression and anxiety were 61% [95% confidential interval(CI):(48%,72%)] and 64% [95% CI:(42%,81%)]among Chinese schistosomiasis patients.Both the SDS [1.45 points,95% CI:(1.30,1.60) points] and SAS scores [2.21 points,95% CI:(2.05,2.38) points] reduced among Chinese schistosomiasis patients after psychological interventions than before psychological interventions,and the SDS [-0.47 points,95% CI:(-6.90,-0.25) points] and SAS scores [-1.30 points,95% CI:(-1.52,-1.09) points] reduced among Chinese schistosomiasis patients in the case group than in the control group.Conclusions The comorbid anxiety and depression are common among Chinese schistosomiasis patients,and conventional psychological interventions facilitate the improvements of anxiety and depression among schistosomiasis patients.

关 键 词：血吸虫病 共病 抑郁 焦虑 心理干预 META分析 

分 类 号：R532.21[医药卫生—内科学]