非编码RNA在广州管圆线虫感染中作用和机制研究进展  

Progress of researches on the role and mechanisms of non-coding RNA in Angiostrongylus cantonensis infection

作　　者：程东慧 李中秋 曾文博 蒋天哥 郭云海 张仪 CHENG Donghui;LI Zhongqiu;ZENG Wenbo;JIANG Tiange;GUO Yunhai;ZHANG Yi(National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(National Center for Tropical Diseases Research),National Health Commission Key Laboratory of Parasite and Vector Biology,WHO Collaborating Centre for Tropical Diseases,National Center for International Research on Tropical Diseases,Shanghai 200025,China;School of Global Health,National Center for Tropical Disease Research and Shanghai Jiao Tong University,Shanghai 200025,China)

机构地区：[1]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)、国家卫生健康委员会寄生虫病原与媒介生物学重点实验室、WHO热带病合作中心、国家级热带病国际联合研究中心,上海200025 [2]上海交通大学医学院-国家热带病研究中心全球健康学院,上海200025

出　　处：《中国血吸虫病防治杂志》2023年第4期407-412,共6页Chinese Journal of Schistosomiasis Control

基　　金：国家重点研发计划(2021YFC2300800,2021YFC2300802);上海市青年科技英才扬帆计划(21YF1452200)。

摘　　要：广州管圆线虫是一种食源性人兽共患寄生虫,人体感染后可引起嗜酸性脑膜炎。非编码RNA(non-coding RNAs,ncRNAs)能在多个生物水平调控生理与病理过程,但目前对ncRNA在广州管圆线虫感染过程中的调控作用报道较少。本文通过检索PubMed、万方数据知识服务平台和中国知网等数据库,对搜集的文献进行汇总分析,发现ncRNA对广州管圆线虫感染宿主的调节机制主要包括免疫反应、细胞凋亡和信号传导等,且其可用于广州管圆线虫病诊断。本文总结了ncRNA在广州管圆线虫感染过程中的主要作用及其潜在机制,从而为广州管圆线虫病诊断和治疗提供参考。Angiostrongylus cantonensisis a food-borne zoonotic parasite,and human infection may cause eosinophilic meningitis.Non-coding RNAs(ncRNAs) may regulate physiological and pathological processes at multiple biological levels;however,there are few studies pertaining to the regulatory role of ncRNAs in A.cantonensis infection.Based on publications retrieved from PubMed,Wanfang Data and CNKI,the regulatory role of ncRNAs in A.cantonensis infections mainly includes immune responses,cell apoptosis and signaling transduction,and ncRNAs may serve as biomarkers for diagnosis of angiostrongyliasis.This review summarizes the main roles of ncRNAs in A.cantonensis infections and the underlying mechanisms,so as to provide insights into diagnosis and treatment of angiostrongyliasis.

关 键 词：广州管圆线虫 非编码RNA 调控作用 分子机制 

分 类 号：R383.19[医药卫生—医学寄生虫学]