深圳市首例输入性内脏利什曼病报道  

The first imported case of visceral leishmaniasis in Shenzhen City

作　　者：黄燕飞[1] 高世同[2] 李媛[2] HUANG Yanfei;GAO Shitong;LI Yuan(Nanshan District Center for Disease Control and Prevention,Shenzhen,Guangdong 518054,China;Shenzhen Center for Dis-ease Control and Prevention,Shenzhen,Guangdong 518055,China)

机构地区：[1]广东省深圳市南山区疾病预防控制中心,广东深圳518054 [2]广东省深圳市疾病预防控制中心,广东深圳518055

出　　处：《中国血吸虫病防治杂志》2023年第4期424-426,共3页Chinese Journal of Schistosomiasis Control

基　　金：广东省深圳市医学重点学科传染病防控项目(SZXK064)。

摘　　要：本文报道1例主要临床表现为发热、畏寒、伴全血细胞减少的患者。为查明病因,采集患者外周血,应用宏基因组二代测序筛查病原体,检出杜氏利什曼原虫序列;患者骨髓涂片见利什曼原虫无鞭毛体,确诊为内脏利什曼病。给予两性霉素B脂质体治疗14 d,患者痊愈出院。该病例为深圳市自1979年建市以来报道的首例输入性内脏利什曼病病例。A patient with fever,chills,and pancytopenia as major clinical manifestations was presented.To investigate the cause,the patient's peripheral blood was collected for pathogen screening using metagenomic next-generation sequencing(mNGS).The DNA sequence of Leishmania donovani was detected,and Leishmania amastigotes were found in bone marrow smears using microscopy.The case was therefore definitively diagnosed as visceral leishmaniasis,and was cured and discharged from hospital following treatment with liposomal amphotericin B for 14 days.This is the first imported case of visceral leishmaniasis since the founding of Shenzhen City in 1979.

关 键 词：内脏利什曼病 杜氏利什曼原虫 输入性病例 深圳市 

分 类 号：R531.6[医药卫生—内科学]