2020—2021年遂宁市3起诺如病毒聚集性疫情病原学特征研究  

Etiological characteristics of three cluster infections associated with norovirus in Suining City

作　　者：夏燕平[1] 陈器[1] 卢艺 敬永计 贺泽刚 杨梅 孙敏 曹冉冉[2] XIA Yanping;CHEN Qi;LU Yi;JING Yongji;HE Zegang;YANG Mei;SUN Min;CAO Ranran(Suining Center for Disease Control and prevention,Suining 629000,Sichuan Province,China;Sichuan Center for Disease Control and prevention,Chengdu 610041,Sichuan Province,China)

机构地区：[1]遂宁市疾病预防控制中心,四川遂宁629000 [2]四川省疾病预防控制中心,成都610041

出　　处：《预防医学情报杂志》2023年第10期1184-1189,共6页Journal of Preventive Medicine Information

摘　　要：目的分析四川省遂宁市诺如病毒聚集性疫情中病毒的基因型及进化特征,为疫情防控提供参考。方法采集2020—2021年遂宁市3起诺如病毒聚集性疫情中病例、健康人(托幼机构教师和厨师)肛拭子标本及环境涂抹标本,采用实时荧光RT-PCR检测诺如病毒核酸,阳性标本进行基因同源性和系统进化分析。结果3起疫情共报告病例34例,波及3个班级132人,总罹患率为25.76%(34/132);采集到的19份病例标本中,13份阳性;5份教职工标本中1份阳性;20份环境标本中3份阳性。成功鉴定8份病例标本基因型,其中2份为GI.5[P4]型,6份为GII.2[P16]型,2起疫情GII.2[P16]型的基因同源性为100%。结论2020—2021年监测到GI.5[P4]、GII.2[P16]2种基因型诺如病毒在遂宁地区流行,系统分析及时预警,有助于学校聚集性疫情防控工作开展。Objective To investigate the genotype and evolutionary characteristics of norovirus in Suining City,Sichuan Province,to provide reference for epidemic prevention and control.Methods Anal swab specimens were collected from cases,healthy people(teachers and cooks in kindergartens),and environmental swabs from three clusters of norovirus outbreaks in Suining city from 2020 to 2021.Norovirus nucleic acid was detected by real-time RT-PCR,and the positive samples were analyzed for gene homology and phylogenetic evolution.Resμlts In total,34 cases were reported in the 3 outbreaks and involved 132 individuals in 3 classes,giving an overall prevalence of 25.76%(34/132).Thirteen of 19 case specimens were positive,1 out of 5 staff specimens were positive,and 3 out of 20 environmental specimens were positive.Genotypes of eight case specimens were successfully identified,of which two were GI.5[P4]type,six were GII.2[p16]type,and the gene homology between the two outbreaks GII.2[p16]type was 100%.Conclusions From 2020 to 2021,two genotypes of norovirus,GI.5[P4]and GII.2[P16],were detected in Suining.Systematic analysis and timely early warning are helpful for the prevention and control of cluster epidemics in schools.

关 键 词：诺如病毒 聚集性疫情 病原学特征 

分 类 号：R512.5[医药卫生—内科学]