某灵芝孢子油软胶囊对小鼠抗疲劳作用  

Anti-fatigue effect of a ganoderma lucidum spore oil soft capsule on mice

作　　者：熊亚茹 肖丽佳 谭满意 胡余明[1] XIONG Yaru;XIAO Lijia;TAN Manyi;HU Yuming(Hunan Center for Disease Control and Prevention,Changsha 410005,Hunan Province,China)

机构地区：[1]湖南省疾病预防控制中心,长沙410005

出　　处：《预防医学情报杂志》2023年第10期1225-1229,共5页Journal of Preventive Medicine Information

摘　　要：目的分析某灵芝孢子油软胶囊对小鼠的抗疲劳作用效果。方法将SPF级昆明种雄性小鼠随机分为对照组、低剂量(0.20 g/kg·bw)、中剂量(0.40 g/kg·bw)和高剂量(1.20 g/kg·bw)组。采用负重游泳实验,结合血清尿素、肝糖原和血乳酸含量测定,分析某灵芝孢子油软胶囊对小鼠的抗疲劳作用。使用SPSS 22.0软件进行统计分析,以P<0.05为差异有统计学意义。结果与对照组相比,高剂量组负重游泳时间延长(t=3.243,P=0.007)、中剂量组的肝糖原水平升高(t=2.861,P=0.019)、低剂量组的血乳酸水平降低(t=3.061,P=0.011);而不同剂量组的血尿素水平差异均无统计学意义(P均>0.05)。结论某灵芝孢子油软胶囊对小鼠具有一定的抗疲劳作用。Objective To analyze the anti-fatigue effect of a ganoderma lucidum spore oil soft capsule on mice.Methods SPF(specified pathogen free)grade Kunming male mice were randomly divided into control group,low dose(0.20 g/kg·bw),medium dose(0.40 g/kg·bw)and high dose(1.20 g/kg·bw)groups.The anti-fatigue effect of a ganoderma lucidum spore oil soft capsule on mice was analyzed via weight-bearing swimming test combined with determination of the contents of serum urea,liver glycogen and blood lactic acid.SPSS 22.0 software was used for statistical analysis,and P<0.05 was considered statistically significant.Results Compared with the control group,the time of weight-bearing swimming in the high-dose group was extended(t=3.243,P=0.007),the level of liver glycogen in the medium-dose group was increased(t=2.861,P=0.019),and the level of blood lactic acid in the low-dose group was decreased(t=3.061,P=0.011).There was no statistically significant difference in blood urea level among different dose groups(all P>0.05).Conclusions The ganoderma lucidum spore oil soft capsule exhibited certain anti-fatigue effect on mice.

关 键 词：灵芝孢子油 抗疲劳 功效评价 

分 类 号：R285.5[医药卫生—中药学]