中药防治人工关节置换术后假体无菌性松动的研究进展  

Research progress in the prevention and treatment of aseptic loosening of prostheses after artificial joint replacement with traditional Chinese medicine

作　　者：刘文成 王鑫 李庆雷 杨广华 LIU Wencheng;WANG Xin;LI Qinglei;YANG Guanghua(Shandong Wendeng Osteopaths Yantai Hospital,Yantai Shandong 264000)

机构地区：[1]山东文登整骨烟台医院,山东烟台264000

出　　处：《当代医药论丛》2023年第20期7-10,共4页

基　　金：山东省中医药科技青年项目(2020Q094)。

摘　　要：人工关节假体无菌性松动是人工关节置换术后二次手术的主要原因之一,其具有治愈难度大、预后效果差等特点。所以如何预防以及治疗假体松动成为临床医生关注的重点。炎性因子、破骨细胞、成骨细胞以及相关信号通路都是影响人工关节置换术后假体产生无菌性松动和引发假体周围骨溶解的重要因素。中药预防假体无菌性松动可以从多个途径对骨代谢进行调节,随着研究的深入,中药在防治假体无菌性松动方面取得良好的发展,本文从中医补肾理论着手总结中药通过调控炎性因子、破骨细胞、成骨细胞以及相关信号通路防治人工关节置换术后假体无菌性松动的研究进展,并作一综述。Aseptic loosening of artificial joint prosthesis is one of the main reasons for the second operation after artificial joint replacement,which has the characteristics of difficult cure and poor prognosis.Therefore,how to prevent and treat prosthesis loosening has become the focus of clinicians’attention.Inflammatory factors,osteoclasts,osteoblasts and related signaling pathways are important factors that affect the aseptic loosening of prosthesis after artificial joint replacement and cause osteolysis around prosthesis.The prevention of prosthesis aseptic loosening by traditional Chinese medicine can regulate bone metabolism in multiple ways.With the deepening of research,traditional Chinese medicine has achieved good development in the prevention and treatment of prosthesis aseptic loosening.Based on the theory of tonifying kidney in Chinese medicine,this paper summarizes the research progress of preventing and treating aseptic loosening of prosthesis after artificial joint replacement by regulating inflammatory factors,osteoclasts,osteoblasts and related signaling pathways.

关 键 词：中药 人工关节置换术 磨损颗粒 假体松动 

分 类 号：R68[医药卫生—骨科学]