母体免疫激活导致子代精神分裂症的机制研究进展  

Research progress on the mechanism of schizophrenia in offspring induced by maternal immune activation

作　　者：金阳 刘馨洁 黄嘉琦 王钰冰 陈琦 宋盟 吕路线[2] JIN Yang;LIU Xinjie;HUANG Jiaqi;WANG Yubing;CHEN Qi;SONG Meng;LYU Luxian(The Second Clinical College,Xinxiang Medical University,Xinxiang 453003,Henan Province,China;Henan Key Laboratory of Biological Psychiatry,the Second Affiliated Hospital of Xinxiang Medical University,Xinxiang 453002,Henan Province,China)

机构地区：[1]新乡医学院第二临床学院,河南新乡453003 [2]新乡医学院第二附属医院河南省生物精神病学重点实验室,河南新乡453002

出　　处：《新乡医学院学报》2023年第11期1087-1090,共4页Journal of Xinxiang Medical University

基　　金：国家级大学生创新创业训练计划项目(编号:202010472026);河南省生物精神病学重点实验室开放课题(编号:ZDSYS2018003)。

摘　　要：精神分裂症(SCZ)是一种重型精神疾病,20世纪末我国SCZ的发病率高达5.69%。虽然,现有抗精神病药物对SCZ患者的临床症状具有一定的改善作用,但仍有约1/3的患者对药物的反应不佳,SCZ已成为全球性公共卫生问题。SCZ病因复杂,其发病机制尚不明确。研究发现,母体免疫激活(MIA)可引起子代中枢神经免疫系统、神经递质系统、突触可塑性以及脑-肠轴功能等异常改变,从而增加子代患SCZ的风险。基于此,本文就MIA导致子代患SCZ的临床证据、病理改变和相关机制研究进行综述。Schizophrenia(SCZ)is a serious neuropsychiatric disorder,with an incidence of 5.69%in China at the end of th E20 th century.Although the antipsychotic drugs have a certain improvement effect on the clinical symptoms of SCZ patients,but about 1/3 of patients still have poor response to the drugs,SCZ has become a global public health problem.The etiology of SCZ is complex,and its pathogenesis is still unclear.Maternal immune activation(MIA)can cause abnormal changes of central nervous immune system,neurotransmitter system,synaptic plasticity and brain-gut axis function in offspring,thus increasing the risk of SCZ in offspring.Based on this,this article reviews the clinical evidence,pathological changes and related mechanisms of SCZ in offspring induced by MIA.

关 键 词：母体免疫激活 精神分裂症 小胶质细胞 神经递质紊乱 免疫调节 

分 类 号：R794.3[医药卫生—临床医学]