活血接骨汤联合复方骨肽对跟骨骨折术后患者血液流变学、骨代谢因子的影响  

Influence of Huoxue Jiegu decoction combined with compound bone peptide on hemorheology and bone metabolic factors of patients after calcaneal fracture

作　　者：黄永红[1] 陆江涛[1] 黄建国[1] 胡春祥 王自耿 HUANG Yonghong;LU Jiangtao;HUANG Jianguo;HU Chunxiang;WANG Zigeng(Four Department of Bone,Sanya Traditional Chinese Medicine Hospital,Sanya 572000,China)

机构地区：[1]三亚市中医院骨四科,海南三亚572000

出　　处：《陕西中医》2023年第11期1558-1561,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：海南省卫生计生行业科研项目(19A200113)。

摘　　要：目的:观察活血接骨汤联合复方骨肽对跟骨骨折术后患者血液流变学、骨代谢因子的影响。方法:选取108例跟骨骨折患者,采用信封法随机分为两组。对照组(n=52)给予复方骨肽注射液治疗,联合组(n=56)在对照组基础上给予活血接骨汤治疗。比较两组首次皮纹出现时间、住院时间、张力性水疱发生率、血液流变学、血清相关因子、中医证候积分、不良反应发生率。结果:联合组首次皮纹出现时间、住院时间短于对照组,张力性水疱发生率低于对照组,差异有统计学意义(均P<0.05)。两组治疗1、3、5 d后疼痛评分均较治疗前降低,且联合组低于对照组,差异有统计学意义(均P<0.05)。治疗1、3、5 d后肿胀消除率高于对照组(P<0.05)。治疗后两组中医证候积分、血液流变学指标、缺氧诱导因子-α、肿瘤坏死因子-α低于治疗前,且联合组低于对照组,差异有统计学意义(均P<0.05)。治疗后两组血清骨保护素、胰岛素样生长因子、Ⅰ型前胶原羧基端肽、骨形态发生蛋白高于治疗前,且联合组高于对照组,差异有统计学意义(均P<0.05)。联合组不良反应率与对照组比较,差异无统计学意义(P>0.05)。结论:活血接骨汤联合复方骨肽注射液能促进跟骨骨折患者缓解疼痛、消退肿胀,改善血液流变学、骨代谢。Objective:To observe effects of Huoxue Jiegu decoction combined with compound bone peptide on hemorheology and bone metabolic factors of patients after calcaneal fracture.Methods:108 patients with calcaneal fracture were randomly divided into two groups by envelope method.The control group(n=52)were treated with compound bone peptide injection,and combined group(n=56)treated with Huoxue Jiegu decoction on the basis of the control group.The time of first appearance of skin marks,length of hospital stay,incidence of tension blister,hemorheology,serum related factors,TCM syndrome scores,incidence of adverse reactions between the two groups were compared.Results:The time of appearance of the first skin line,hospital stay,incidence of tension blistersin the combined group were shorter than those in the control group,difference statistically significant(all P<0.05).The pain scores of the two groups after 1,3 and 5 days of treatment were lower than those before treatment,and the combined group were lower than those in the control group,difference statistically significant(all P<0.05).The reduction rate of swelling after 1,3 and 5 days of treatment were higher than those in the control group,difference statistically significant(all P<0.05).After treatment,TCM syndrome score,hemorheology index,hypoxia-induced-factor-αand tumor necrosis factor-αwere lower in the two groups than before treatment,and the combined group were lower than those in the control group,difference statistically significant(all P<0.05).After treatment,serum osteophorin,insulin-like growth factor,carboxy-terminal peptide of typeⅠprocollagen and bone morphogenetic protein in two groups were higher than before treatment,and the combined group were higher than those in the control group,difference statistically significant(all P<0.05).The adverse reaction rate of combination group was compared with that in the control group,difference not statistically significant(P>0.05).Conclusion:The treatment of calcaneal fracture with Huoxue Jiegu decoction combi

关 键 词：跟骨骨折 活血接骨汤 复方骨肽注射液 血液流变学 血清因子 骨代谢 不良反应 

分 类 号：R683[医药卫生—骨科学]