绝经前后女性医务人员维生素D水平及其影响因素  

Vitamin D levels in postmenopausal female medical staff and its influencing factors

作　　者：章静菲 白文佩 任正洪[2] 时正媛[3] 王小雪 王子君 ZHANG Jingfei;BAI Wenpei;REN Zhenghong;SHI Zhengyuan;WANG Xiaoxue;WANG Zijun(Department of Gynecology,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing,100038;Department of Women and Child Adolescent Health,School of Public Health of Health Science Center of Peking University,Beijing,100191;Department of Pharmacy,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing,100038)

机构地区：[1]首都医科大学附属北京世纪坛医院妇科,北京100038 [2]北京大学医学部公共卫生学院妇女与儿童青少年卫生学系,北京100191 [3]首都医科大学附属北京世纪坛医院药剂科,北京100038

出　　处：《实用临床医药杂志》2023年第18期118-122,共5页Journal of Clinical Medicine in Practice

基　　金：北京市医院管理中心“扬帆”计划重点医学专业项目(ZYLX202112)。

摘　　要：目的 分析绝经前后女性医务人员维生素D水平及其影响因素。方法 选取169例40~55岁女性医务人员为研究对象。采用问卷调查受试者基本信息、月经状况、既往病史、生活方式、补充维生素D、绝经激素治疗(MHT)等情况。检测受试者血清25羟基维生素D[25(OH)D]、抗苗勒氏管激素(AMH)、卵泡生成素(FSH)和雌激素(E2)水平。分析维生素D缺乏的影响因素。结果 受试者中位年龄为47(43, 51)岁;生育晚期106例,绝经过渡期34例,绝经后早期29例;血清25(OH)D平均水平为11.4(9.3, 15.7) ng/mL。血清25(OH)D水平正常者17例(10.06%),不足57例(33.73%),缺乏95例(56.21%)。117例(69.23%)每日接受不到日照,49例(28.99%)每日日照时间短于0.5 h, 3例(1.78%)每日日照时间达0.5 h及以上。从未补充维生素D(OR=2.317, 95%CI:1.198~4.482,P<0.05)和从未接受MHT(OR=2.522, 95%CI:1.141~5.573,P<0.05)是绝经前后女性医务人员维生素D缺乏的危险因素。结论 绝经前后女性医务人员维生素D普遍缺乏,该类人群应增加室外活动、补充维生素D。Objective To analyze the levels of vitamin D in postmenopausal female medical staff and its influencing factors.Methods A total of 169 female medical staff aged 40 to 55 years were selected as the study subjects.The subjects'basic information,menstrual status,past medical history,lifestyle,vitamin D supplementation and menopausal hormone therapy(MHT)were investigated by questionnaire.Serum levels of 25 hydroxyvitamin D[25(OH)D],anti-Mullerian hormone(AMH),follicle-producing hormone(FSH)and estrogen(E 2)were measured.The influencing factors of vitamin D deficiency were analyzed.Results The median age of participants was 47(43,51)years;there were 106 cases in late reproductive period,34 cases in menopausal transition period and 29 cases in early postmenopausal period.The average level of serum 25(OH)D was 11.4(9.3,15.7)ng/mL.Serum 25(OH)D level was normal in 17 cases(10.06%),insufficient in 57 cases(33.73%),and deficient in 95 cases(56.21%).One hundred and seventeen cases received no sunshine daily(69.23%),49 cases(28.99%)received less than 0.5 h of sunshine daily,and 3 cases(1.78%)received 0.5 h or more sunshine daily.Never supplemented with vitamin D(OR=2.317;95%CI,1.198 to 4.482;P<0.05)and never receiving MHT(OR=2.522;95%CI,1.141 to 5.573;P<0.05)were risk factors for vitamin D deficiency in postmenopausal female medical staff.Conclusion Vitamin D deficiency is common among postmenopausal female medical staff,and these people should increase outdoor activities and supplement vitamin D.

关 键 词：维生素D 绝经 更年期 卵巢功能 抗苗勒氏管激素 危险因素 

分 类 号：R711.75[医药卫生—妇产科学] R591.44[医药卫生—临床医学]