子痫前期患者胎盘组织Toll样受体表达与血清肿瘤坏死因子-α、白细胞介素-6的相关性分析  

Correlation Analysis of Toll-like Receptor Expression in Placental Tissue and Serum Tumor Necrosis Factor-αand Interleukin-6 in Patients with Preeclampsia

作　　者：陈海霞 程静 赵华[1] 梁洁 CHEN Haixia;CHENG Jing;ZHAO Hua(Wuxi Woman and Enfants Care Hospital,Wuxi City,Jiangsu Province 214000)

机构地区：[1]江苏省无锡市妇幼保健院病理科,214000

出　　处：《医学理论与实践》2023年第21期3623-3625,3629,共4页The Journal of Medical Theory and Practice

摘　　要：目的:分析子痫前期(PE)患者胎盘组织Toll样受体表达(TLRs)与血清肿瘤坏死因子(TNF)-α、白细胞介素-6(IL-6)的相关性。方法:选定本院妇产科2020年11月—2022年10月就诊的112例PE患者为P组,另选定同期本院妇产科待产的112例健康产妇为I组,检测、比较两组胎盘组织TLRs及血清TNF-α、IL-6水平,比较不同严重程度组胎盘组织TLRs及血清TNF-α、IL-6水平,比较有、无不良妊娠结局组胎盘组织TLRs及血清TNF-α、IL-6水平,对TLRs与TNF-α、IL-6的相关性进行Pearson分析,通过ROC曲线分析血清TNF-α、IL-6对PE患者不良妊娠结局预测效能。结果:P组胎盘组织TLRs、血清TNF-α、IL-6水平均高于I组(P<0.05)。重度组胎盘组织TLRs、血清TNF-α、IL-6水平均高于轻度组(P<0.05)。有不良妊娠结局组胎盘组织TLRs、血清TNF-α、IL-6水平均高于无不良妊娠结局组(P<0.05)。TLRs与TNF-α、IL-6均呈正相关性(r=0.406、0.398,P<0.05)。血清TNF-α、IL-6联合检测预测PE患者不良妊娠结局的AUC是0.919(95%CI:0.796~0.958),且其灵敏度、特异度均高于单一检测(P<0.05)。结论:PE患者胎盘组织TLRs与血清TNF-α、IL-6呈正相关性,共同参与了PE疾病进展中,血清TNF-α、IL-6联合检测可提高对不良妊娠结局的预测效能。Objective:To analyze the correlation between toll-like receptor expression(TLRs)in placental tissue and serum tumor necrosis factor(TNF)-αand interleukin-6(IL-6)in patients with preeclampsia(PE).Methods:A total of 112 PE patients in the department of Obstetrics and Gynecology of our hospital from November 2020 to October 2022 were selected as group P,and 112 healthy pregnant women in the department of Obstetrics and Gynecology of our hospital during the same period were selected as group I.The levels of placental tissue TLRs,serum TNF-αand IL-6 were detected and compared between the two groups.The levels of TLRs,serum TNF-αand IL-6 in placental tissue of different severity groups were compared,and the levels of TLRs,serum TNF-αand IL-6 in placental tissue of groups with and without adverse pregnancy outcome were compared.The correlation between TLRs and TNF-αand IL-6 was analyzed by Pearson analysis.The predictive efficacy of serum TNF-αand IL-6 on adverse pregnancy outcome in PE patients was analyzed by ROC curve.Results:The levels of placental TLRs,serum TNF-αand IL-6 in group P were higher than those in group I(P<0.05).The levels of placental TLRs,serum TNF-αand IL-6 in severe group were higher than those in mild group(P<0.05).The levels of placental tissue TLRs,serum TNF-αand IL-6 in the group with adverse pregnancy outcome were higher than those in the group without adverse pregnancy outcome(P<0.05).TLRs were positively correlated with TNF-αand IL-6(r=0.406,0.398,P<0.05).The AUC of serum TNF-αand IL-6 combined test for predicting adverse pregnancy outcome in PE patients was 0.919(95%CI:0.796~0.958),and the sensitivity and specificity were higher than that of single test(P<0.05).Conclusion:TLRs of placental tissue in PE patients are positively correlated with serum TNF-αand IL-6,which are involved in the progression of PE disease.The combined detection of serum TNF-αand IL-6 can improve the predictive efficacy of adverse pregnancy outcomes.

关 键 词：子痫前期 Toll样受体表达 肿瘤坏死因子-α 白细胞介素 

分 类 号：R714.245[医药卫生—妇产科学]