光声骨检测研究进展  

Photoacoustic bone characterization:A progress review

作　　者：封婷 解维娅 徐文逸 高雅[1] 刘腾 他得安 钱梦騄[1] 程茜[1] Ting Feng;Weiya Xie†;Wenyi Xu;Ya Gao;Teng Liu;Dean Ta;Menglu Qian;Qian Cheng(Institute of Acoustics,School of Physics Science and Engineering,Tongji University,Shanghai 200092,China;Academy for Engineering and Technology,Fudan University,Shanghai 200433,China;Department of Electronic Engineering,Fudan University,Shanghai 200433,China;School of Electronic and Optical Engineering,Nanjing University of Science and Technology,Nanjing 210094,China)

机构地区：[1]同济大学物理科学与工程学院声学研究所,上海200092 [2]复旦大学工程与应用技术研究院,上海200433 [3]复旦大学信息科学与工程学院,上海200433 [4]南京理工大学电子工程与光电技术学院,南京210094

出　　处：《科学通报》2023年第26期3437-3454,共18页Chinese Science Bulletin

基　　金：国家自然科学基金(12034015,11827808)资助。

摘　　要：光声成像及检测技术兼具生物组织对光的选择吸收特性及超声波的穿透深度优势,可提供生物组织的宏观生理结构和微观分子层面的影像信息,在医学检测中有着巨大的应用潜力.其中,光声骨成像及检测技术是光声成像临床应用领域的重要分支.然而,骨组织是固液两相复杂介质(固相为矿化的骨小梁网络,液相为嵌入的骨髓),这种各向异性的非均匀结构使得基于光声技术的骨组织表征方法面临很大挑战.本文系统讨论了面向复杂骨组织的光声检测及成像机制,包括光声在骨组织中的产生及传播理论、光声谱分析方法、光声骨成像方法及临床应用研究.针对现有的技术研究现状,分析了光声骨成像及检测领域当前所面临的挑战,展望了未来的发展趋势.Bone diseases are chronic diseases that cause changes in the physical structure and chemical composition of the bones.The incidence of bone diseases ranks first among the five major diseases of middle-aged and elderly people,causing significant strain on public health resources.The early prevention and treatment of bone diseases can avoid the occurrence of bone tumors,fractures and other serious bone diseases as well as a series of complications.Therefore,for the early screening and early diagnosis of bone diseases,it is urgent to develop diagnostic methods that can be easily promoted and can evaluate bone health.Based on the clinical requirements for the detection of physical structure characteristics and molecular metabolism characteristics of bone tissues,the development of a non-invasive and non-radiative in vivo detection method that can simultaneously evaluate the microstructure and metabolic information of bone is of great scientific significance and clinical value for the early diagnosis,treatment and monitoring of bone diseases.Photoacoustic imaging(PAI)combines the advantages of selective optical absorption of different chromophores in biological tissues and high penetration depth of ultrasound,providing imaging information on the macroscopic physiological structure and microscopic molecular level of biological tissues.Thus,it has great potential in the application of biomedical imaging.Among them,PAI and PA detection technology of bone is an important branch of clinical application fields.However,bone tissue is a complex biological medium.From the perspective of physical structures,the whole bone tissue can be regarded as a non-uniform layered curved structure composed of soft tissue,cortical bone and cancellous bone,in which cancellous bone is a solid-liquid two-phase porous structure(the bone trabecular frame can be regarded as the solid phase,and bone marrow clusters filled in the pores can be regarded as the liquid phase).In terms of chemical composition,bone tissue is composed of a variety of chem

关 键 词：光声成像 复杂介质 骨代谢功能 骨微结构 

分 类 号：TP391.41[自动化与计算机技术—计算机应用技术] R318.51[自动化与计算机技术—计算机科学与技术]