Steroid and triterpenoid saponins from the rhizomes of Paris polyphylla var.stenophylla  

作　　者：HU Jinming LU Yunyang ZHENG Shuxian TIAN Yunyuan LI Tianyi TANG Haifeng YANG Zhao LIU Yang 

机构地区：[1]Department of Chinese Medical and Natural Medicines,School of Pharmacy,Air Force Medical University,Xi'an 710032,China [2]Department of Military Medical Psychology,Air Force Military Medical University,Xi'an 70032,China

出　　处：《Chinese Journal of Natural Medicines》2023年第10期789-800,共12页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81973192 and 81902185);the Key Research and Development Projects of Shaanxi Province(Nos.2021ZDLSF04-07,2021SF-175 and 2022SF-314);the Natural Science Basic Research Program of Shaanxi Province(No.2022JQ-780);the Key Scientific Research Project of Shaanxi Administration of Traditional Chinese Medicine(No.2021-02-ZZ-003).

摘　　要：Five new saponins,including three steroid saponins,paristenoids A-C(1-3),and two triterpenoid saponins,paristenoids D-E(4-5),along with four known ones(6-9)were isolated from the rhizomes of Paris polyphylla var.stenophylla.The structures of the isolated compounds were identified nainly by detailed spectroscopic analysis,including extensive 1D and 2D NMR,MS,as well as chemical methods.Compound 3 is a new cyclocholestanol-type steroidal saponin with a rare 6/6/6/5/5 fused-rings cholestanol skeleton,and this skeleton has been first found from the genus Paris.The cytotoxicities of the isolated compounds against three human three glioma cell lines(U87MG,U251MG and SHG44)were evaluated,and compound 7 displayed certain inhibitory effect with ICso values of 15.22±1.73,18.87±1.81 and 17.64±1.69μmol^(-1),respectively.

关 键 词：Paris polyphylla var.stenophylla Steroid saponins Triterpenoid saponins Cyclocholestanol-type 

分 类 号：R284.1[医药卫生—中药学]