氨甲基树脂固载手性双烯配体-铑催化剂的制备及催化不对称1,4加成反应的研究  

Preparation of Chiral Diene Ligands-Rhodium Catalyst Supported by Aminomethyl Resin and Its Catalysis on Asymmetric 1,4-Addition Reaction

作　　者：师壮壮 赵子富 罗云飞 Shi Zhuangzhuang;Zhao Zifu;Luo Yunfei(School of Chemistry and Chemical Engineering,Hefei University of Technology,Hefei,Anhui 230009,China)

机构地区：[1]合肥工业大学化学与化工学院,安徽合肥230009

出　　处：《化学世界》2023年第6期425-430,共6页Chemical World

摘　　要：从(R)-α-水芹烯和丙炔酸甲酯开始合成手性双烯配体,再与氨甲基(AM)树脂反应并络合铑得到固载铑的催化剂。用得到的固载催化剂进行一系列α,β不饱和酮与苯硼酸的不对称1,4加成反应。研究结果表明,合成的固载化催化剂参与的反应在温和的反应条件下产率为70%~80%,ee为70%~90%,而且合成的固载化铑催化剂具有很好的重复利用性。The chiral diene ligand synthesized from(R)-α-phellandrene and methyl propiolate was successfully immobilized on aminomethyl resin and then complexed with rhodium to give a rhodium-supported chiral catalyst.A series of asymmetric 1,4-addition reactions ofα,β-unsaturated ketones with phenylboronic acid were performed using the obtained supported catalyst.The results showed that the yield using this catalyst can reach 70%~80%under mild conditions with 70%~90%ee.This rhodium-supported catalyst has good reusability.

关 键 词：手性双烯配体 固载化铑催化剂 不对称1 4-加成反应 

分 类 号：O626.11[理学—有机化学]