普朗尼克胶束的制备及在肿瘤治疗中的应用  

Preparation of Pluronic micelles and their application in tumor therapy

作　　者：张婕 王东凯[1] ZHANG Jie;WANG Dongkai(School of Pharmacy,Shenyang Pharmaceutical University,Shenyang 110016,China)

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《中国药剂学杂志（网络版）》2023年第5期282-297,共16页Chinese Journal of Pharmaceutics：Online Edition

摘　　要：目的综述普朗尼克胶束现有的制备方法以及其在肿瘤治疗中的应用,期望为普朗尼克胶束后续研究提供参考。方法查阅近年来国内外普朗尼克胶束的相关文献,分别总结了现有的普朗尼克胶束的制备方法以及普朗尼克胶束用于肿瘤治疗的优势。结果普朗尼克可以通过溶剂蒸发法、薄膜水化法、透析法以及直接溶解法制备成普朗尼克胶束用于药物的运输。普朗尼克胶束是一种理想的纳米递送材料,尤其是在肿瘤的治疗中,普朗尼克胶束能够增强药物递送的靶向性,降低药物的毒副作用,逆转肿瘤的多药耐药性,并且能够用于肿瘤的诊断。结论普朗尼克胶束具有广泛的应用前景。Objective The existing preparation methods of Pluronic micelles and their application in tumor treatment are reviewed,and it is expected to provide references for the follow-up research of Pluronic micelles.Method The related literatures of Pluronic micelles at home and abroad in recent years were reviewed,and the existing preparation methods of Pluronic micelles and the advantages of Pluronic micelles for tumor treatment were summarized,respectively.Result Pluronic micelles could be prepared by solvent evaporation,thin film hydration,dialysis and direct dissolution for drug transport.Pluronic micelles are the ideal nano-delivery materials,especially in the treatment of tumors.Pluronic micelles can enhance the targeting of drug delivery,reduce the toxic and side effects of drugs in the treatment of tumors,and can be used for tumor diagnosis.Conclusion Pluronic micelles have broad application prospects.

关 键 词：普朗尼克 普朗尼克胶束 抗肿瘤 聚合物胶束 

分 类 号：R94[医药卫生—药剂学] R730.5[医药卫生—药学]