国际合成生物学领域主题演化的领先-滞后模式研究  

Research on Lead-Lag Pattern of Topic Evolution in the Field of International Synthetic Biology

作　　者：梁爽 刘小平[1,2] 陶治宇 杨举伦 LIANG Shuang;LIU Xiaoping;TAO Zhiyu;YANG Julun(National Science Library,Chinese Academy of Sciences,Beijing 100190,China;Department of Information Resources Management,School of Economics and Management,University of Chinese Academy of Sciences,Beijing 100190,China;Department of Pathology,920th Hospital of the Joint Logistics Support Force of PLA,Kunming 650032,China)

机构地区：[1]中国科学院文献情报中心,北京100190 [2]中国科学院大学经济与管理学院信息资源管理系,北京100190 [3]联勤保障部队第九二〇医院病理科,昆明650032

出　　处：《世界科技研究与发展》2023年第5期633-646,共14页World Sci-Tech R&D

基　　金：国家自然科学基金“交叉科学战略情报研究”(T2241001)。

摘　　要：合成生物学被誉为颠覆未来的前沿技术,明确我国与世界科技强国在合成生物学发展中的相对优劣与差异情况,能够促进科技创新结构的调整优化,把握学科发展的重点领域。本文基于合成生物学领域的论文数据对学科主题进行挖掘并识别研究热点,计算得到主要研究国家关于热点主题发展趋势的时间序列数据,综合灰色关联度与欧氏距离提出关联强度测度指标,并引入互相关方法的基本思想对我国与世界科技强国之间的领先-滞后关系及时滞期进行分析。研究发现,各国主题研究态势具有较为紧密的关联性,我国合成生物学领域整体呈现出滞后于国外的发展局面,美英德三国总体上展现出相对突出的科研实力与领先地位。建议我国继续提升科研成果的产出效率与数量,加大基因表达调控及基因组工程等技术方向的攻关力度,保持代谢工程研究的既往优势。Synthetic biology is known as the frontier technology that subverts the future.Clarifying the strengths and weaknesses of synthetic biology between China and the world’s S&T powerhouses is conducive to adjusting and optimizing the scientific and technological innovation structure,meanwhile helping grasp the key fields of discipline development.We conduct topic mining and identify research hotspots based on paper data in the field of synthetic biology,generating time-series data about the development trend of S&T powerhouses’research hot topics.Combining the grey correlation degree and Euclidean distance,this paper puts forward the correlation strength measurement index and introduces the basic idea of cross correlation method to analyze the lead-lag relationship and the time lag between China and the world’s S&T powerhouses.The research shows that the trend of research topics among various countries is closely related.A time lag phenomenon is observed that the development of synthetic biology in China is left behind compared with foreign countries.The United States,Britain,and Germany have shown relatively outstanding scientific research strength and are maintaining the leading position.The paper suggests that our country continues to improve the efficiency and quantity of research output.We should intensify our efforts in gene expression regulation and genome engineering and maintain the previous advantages of metabolic engineering research.

关 键 词：科技强国 学科发展 主题演化 领先-滞后关系 

分 类 号：Q81[生物学—生物工程]