口腔微生物所致牙周炎在冠心病发病中的机制研究进展  

Research progress on the mechanism of periodontitis caused by oral microorganisms in coronary heart disease

作　　者：陈子君 王以琴 李杰[1] 陈伶利[1,2] CHEN Zijun;WANG Yiqin;LI Jie;CHEN Lingli(Hunan University of Chinese Medicine,Changsha,Hunan 410208,China;Hunan Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine,Changsha,Hunan 410208,China)

机构地区：[1]湖南中医药大学,湖南省长沙市410208 [2]湖南中医药大学中西医结合病原生物学湖南省重点实验室,湖南省长沙市410208

出　　处：《中国动脉硬化杂志》2023年第10期909-915,共7页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(81874375);湖南省重点实验室开放基金项目(2022KFJJ03)。

摘　　要：冠心病作为动脉粥样硬化导致器官病变和危害人类健康的常见疾病之一,其可能的发病机制繁多且复杂,如何防治已成为全球热点健康问题。研究发现,在冠心病发病的危险因素之中,口腔微生物组紊乱引起的各种口腔疾病如牙周炎等,会极大增加冠心病的患病风险。为探讨冠心病与口腔微生物之间的相关性,本综述从口腔微生物对冠心病可能存在的致病机制进行阐述,以期为冠心病的预防和治疗提供新思路和参考。As one of the common diseases caused by atherosclerosis,coronary heart disease has various and complex pathogenesis.How to prevent and treat coronary heart disease has become a global hot health issue.Studies have found that among the risk factors for coronary heart disease,various oral diseases such as periodontitis,caused by oral microbiome disorders,can greatly increase the risk of coronary heart disease.In order to explore the correlation between coronary heart disease and oral microorganisms,this paper discusses the possible pathogenic mechanism of periodontitis caused by oral microorganisms on coronary heart disease,in order to provide new ideas and references for the prevention and treatment of coronary heart disease.

关 键 词：冠心病 牙周炎 口腔微生物 生物膜 

分 类 号：R5[医药卫生—内科学]