纳米材料的适配子传感器及其在医学检测中的应用  

Nanomaterial-based aptasensor and its application in medical detection

作　　者：黎子华 王婷[1] 张焜和[1] LI Zihua;WANG Ting;ZHANG Kunhe(Department of Gastroenterology,The First Affiliated Hospital of Nanchang University,Jiangxi Institute of Gastroenterology&Hepatology,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院消化内科,江西省消化疾病研究所,江西南昌330006

出　　处：《传感器与微系统》2023年第11期1-5,共5页Transducer and Microsystem Technologies

基　　金：国家自然科学基金资助项目(82160444)。

摘　　要：通过指数富集的配体系统进化(SELEX)技术体外筛选产生的适配子,可以高特异性和高亲和力结合生物靶分子,因具有分子体积小、稳定性好、修饰方便等优点,在生物分子检测中应用前景良好。与此同时,纳米材料因其具有表面效应、体积效应和量子尺寸效应,各种具有独特性能的纳米材料在生物领域广泛应用。因此,适配子与纳米材料的结合和应用为医学检测领域提供前所未有的发展机遇。本文在简要介绍适配子和纳米技术的基础上,重点介绍基于纳米材料的适配子传感器及其在医学检测中的应用。Aptamers generated by in vitro screening through systematic evolution of ligands by exponential enrichment(SELEX)technique can bind biological target molecules with high specificity and high affinity and have good potential applications in biomolecule detection due to their small molecular size,good stability and easy modification.Meanwhile,various nanomaterials with unique properties have been widely used in biological fields due to their surface effect,volume effect and quantum size effect.Therefore,the combination of aptamers and nanomaterials and application provides unprecedented development opportunities in the field of medical detection.Nanomaterial-based aptasensors and their applications in medical detection after a brief introduction of aptamers and nanotechnology is focused on.

关 键 词：适配子 纳米材料 适配子传感器 医学检测 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]