Risk estimation of chronic kidney disease in a leptospirosis endemic area: A case-control study from south Andaman Islands of India  

作　　者：Ambreen Fatema Manjunatha Ramu Paluru Vijayachari 

机构地区：[1]ICMR-Regional Medical Research Centre,Port Blair,Post Bag No.13,Dollygunj,Port Blair 744101,Andaman&Nicobar Islands,India

出　　处：《Asian Pacific Journal of Tropical Medicine》2023年第10期463-471,共9页亚太热带医药杂志（英文版）

基　　金：supported by ICMR SRF (Grant 2021-9539/F102).

摘　　要：Objective:To estimate the risk of chronic kidney disease in patients with leptospirosis.Methods:All reported(41890)and later confirmed leptospirosis(1990)cases from 2010-2020 were traced by universal sampling.386 Laboratory-confirmed leptospirosis cases were enrolled and 413 age,gender,area,and occupation matched healthy persons were included as controls.Variables including socio-demographic characteristics,medical history,and health-related behaviours were compared between the two groups and association between these variables and reduced estimated glomerular filtration rate(eGFR)was analyzed with multiple linear regression.Results:The median of eGFR was 49.0(27.0,75.0)mL/min/1.73 m^(2) in the cases and 96.0(72.0,121.0)mL/min/1.73 m^(2) in the controls,showing significant differences(P<0.001).Bivariate analysis showed that leptospirosis seropositivitiy,repeat leptospirosis infection,diabetes,male gender,working in field(sun exposure),COVID-19 infection and smoking had statistically significant association with reduced eGFR.Leptospirosis seropositivity had negative effects on eGFR.Multiple linear regression confirmed that leptospirosis seropositivity had negative effects on eGFR(unstandardised β coefficients=−30.86,95%CI−49.7 to−11.9,P<0.001).Conclusions:Chronic kidney disease is a complex disease with multiple risk factors involved.Exposure to leptospirosis is one of the essential factors in accelerating its progression.

关 键 词：Chronic kidney disease Endemic leptospirosis Estimated glomerular filtration rate(eGFR) 

分 类 号：R514.4[医药卫生—内科学]