Clinical profile,etiology,management and outcome of empyema thoracis associated with COVID-19 infection:A systematic review of published case reports  

作　　者：Yasser Ali Kamal Seham Abdelwakeel Abdel-Gaber 

机构地区：[1]Department of Cardiothoracic Surgery,Faculty of Medicine,Minia University,El-Minya,Egypt [2]Department of Medical Pharmacology,Faculty of Medicine,Minia University,El-Minya,Egypt

出　　处：《Asian Pacific Journal of Tropical Medicine》2023年第8期337-346,共10页亚太热带医药杂志（英文版）

摘　　要：Objective:To explore the clinical features,diagnosis,etiology,treatment,and outcomes of COVID-19 related empyema.Methods:Using PRISMA statement,a systematic search of relevant case reports published between December 2019 and April 2023 was performed through seven databases.The collected data included demographics,clinical manifestations,diagnostic findings,treatment,and outcomes.Results:Thirty-six case reports were identified with 43 cases of empyema.The included cases had a median age of 55 years(range:12-78 years)and 79.1%(34/43)were males.The majority of cases presented during hospitalization for management of acute COVID-19 infection(29/43,67.4%)and Charlson comorbidity index<3(40/43,93.0%).Pseudomonas aeruginosa was the most commonly isolated microorganism from the pleural fluid(9/43,20.9%)and 16.3%of the cases(7/43)had polymicrobial infections.Chest drainage was performed in all cases while surgery was indicated in 24 cases(55.8%).The most common complication of COVID-19-related empyema was broncho-pleural fistula(2/43,4.7%).The mortality rate was 23.3%(10/43).Sepsis and/or multi-organ failure were the most commonly reported causes of death.On univariate analysis,no statistically significant risk factor for mortality was identified.Conclusions:COVID-19-associated empyema has a variety of predisposing factors,time of presentation,clinical features,and causative organisms.Invasive or minimally invasive surgical procedures are performed more frequently than isolated chest drainage.Empyema in COVID-19 patients worsens their prognosis and can lead to serious complications.

关 键 词：COVID-19 SARS-CoV-2 EMPYEMA MICROBIOLOGY Thoracic surgery 

分 类 号：R563[医药卫生—呼吸系统]