基于m^(6)A甲基化探讨痰瘀同治动脉粥样硬化的科学内涵  

Discussion on Scientific Connotation of Treating Atherosclerosis from Perspective of Phlegm and Blood Stasis Based on m^(6)A Methylation

作　　者：李兰兰 吴茜 吕乾瑜 李俊佳 杨盈天 叶雪姣 王师菡[1] LI Lanlan;WU Qian;LYU Ganyu;LI Junjia;YANG Yingtian;YE Xuejiao;WANG Shihan(Guang′anmen Hospital,China Academy of Chinese Medical Sciences,Beijing China 100053;Beijing University of Chinese Medicine,Beijing China 100029)

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]北京中医药大学,北京100029

出　　处：《中医学报》2023年第11期2301-2305,共5页Acta Chinese Medicine

基　　金：国家自然科学基金项目(81473465);北京市科技计划课题项目(Z191100006619025);中国中医科学院科技创新工程课题项目(CL2021A00921)。

摘　　要：“痰瘀互结”是动脉粥样硬化(atherosclerosis,AS)的主要病机。m^(6)A是RNA中最为常见的修饰,其动态平衡的改变会影响AS生理功能。METTL14是一种重要的m^(6)A甲基化酶,在RNA的m^(6)A甲基化过程中起着核心作用。METTL14高表达与中医“痰、瘀”相对应,活血化痰与抑制METTL14高表达在AS的治疗中异曲同工。活血化痰中药对预防和改善动脉粥样硬化有显著效果。"Stagnation of Phlegm and blood stasis"is the main pathogenesis of atherosclerosis(AS).M^(6)A is the most common modification in RNA,and the change of its dynamic balance will affect the physiological function of AS.METTL14 is an important m^(6)A methylase,which plays a central role in the m^(6)A methylation of RNA.The high expression of METTL14 corresponds to phlegm and blood stasis in traditional Chinese medicine.Promoting blood circulation and resolving phlegm and inhibiting the high expression of METTL14 have the same effect in treatment of AS.Traditional Chinese medicine for promoting blood circulation and resolving phlegm has obvious effect on preventing and improving atherosclerosis.

关 键 词：动脉粥样硬化 m^(6)A甲基化 痰瘀同治 METTL14 活血化痰药 

分 类 号：R256.2[医药卫生—中医内科学]