棓丙酯治疗急性ST段抬高型心肌梗死的效果及对心功能的影响  

Effect of Propylgallate in the Treatment of Acute ST-segment Elevation Myocardial Infarction and Its Influence on Cardiac Function

作　　者：苏宝顺 SU Baoshun(Yong’an Municipal Hospital,Yong’an 366000,China)

机构地区：[1]永安市立医院,福建永安366000

出　　处：《中外医学研究》2023年第29期125-128,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨棓丙酯治疗急性ST段抬高型心肌梗死(STEMI)的效果及对心功能的影响。方法:选取2020年2月—2022年2月永安市立医院收治的90例STEMI患者。采用信封法将其分为棓丙酯组(n=45)和对照组(n=45)。对照组给予阿司匹林等常规药物口服治疗,棓丙酯组在此基础上给予棓丙酯注射液静脉滴注治疗。比较两组治疗前后心功能、相关指标及临床疗效。结果:与治疗前相比,治疗后两组左室射血分数(LVEF)均升高,左室舒张末期内径(LVEDD)均降低,且棓丙酯组LVEF高于对照组,LVEDD低于对照组,差异有统计学意义(P<0.05)。治疗后,两组心肌肌钙蛋白I(cTnI)、肌酸激酶同工酶(CK-MB)水平较治疗前均降低,且棓丙酯组低于对照组,差异有统计学意义(P<0.05)。治疗后,两组超敏C反应蛋白(hs-CRP)和N-末端B型脑钠肽前体(NT-proBNP)水平较治疗前均下降,且棓丙酯组低于对照组,差异有统计学意义(P<0.05)。棓丙酯组疗效优于对照组,差异有统计学意义(P<0.05)。结论:棓丙酯治疗STEMI效果显著,可有效改善患者心功能。Objective:To investigate the effect of Propylgallate in the treatment of acute ST-segment elevation myocardial infarction(STEMI)and its influence on cardiac function.Method:A total of 90 patients with STEMI admitted to Yong’an Municipal Hospital from February 2020 to February 2022 were selected.They were divided into Propylgallate group(n=45)and control group(n=45)according to envelope method.The control group was given Aspirin and other conventional drugs orally treatment,and the Propylgallate group was treated with intravenous drip of Propylgallate Injection on this basis.The cardiac function and related indexes before and after treatment and clinical efficacy of the two groups were compared.Result:Compared with before treatment,left ventricular ejection fraction(LVEF)in both groups after treatment were risen,while left ventricular end-diastolic diameter(LVEDD)were reduced,and LVEF in Propylgallate group was higher than that in control group,and LVEDD was lower than that in control group,the differences were statistically significant(P<0.05).After treatment,the levels of cardiac troponin I(cTnI)and creatine kinase isoenzyme(CK-MB)in both groups were decreased compared with those before treatment,and the levels of cTnI and CK-MB in Propylgallate group were lower than those in control group,the differences were statistically significant(P<0.05).After treatment,the levels of hypersensitive C-reactive protein(hs-CRP)and N-terminal pro-B-type brain natriuretic peptide(NT-proBNP)in both groups were decreased compared with those before treatment,and the levels of hs-CRP and NT-proBNP in Propylgallate group were lower than those in control group,the differences were statistically significant(P<0.05).The efficacy in Propylgallate group was better than that in control group,the difference was statistically significant(P<0.05).Conclusion:Propylgallate has a significant effect in the treatment of STEMI and can effectively improve cardiac function of patients.

关 键 词：急性心肌梗死 棓丙酯 肌钙蛋白 

分 类 号：R542.22[医药卫生—心血管疾病]