L_(9)(3^(4))正交试验法优选3种静脉用难溶性抗菌药物调配方法  

Optimization of Solution Preparation Methods of Three Intravenous Insoluble Antibacterial Drugs by the L_(9)(3^(4))Orthogonal Test

作　　者：伊迪热斯江·艾力 刘玉花[1] 艾则孜江·艾尔肯 周静 宋涵[1] Yidiresijiang AILI;LIU Yuhua;Aizezijiang AIERKEN;ZHOU Jing;SONG Han(The First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang,China 830011)

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830011

出　　处：《中国药业》2023年第21期79-82,共4页China Pharmaceuticals

基　　金：2021年新疆维吾尔自治区药学会科研基金项目[YXH202117]。

摘　　要：目的优选哌拉西林钠他唑巴坦钠、头孢呋辛钠、头孢哌酮钠舒巴坦钠3种静脉用难溶性抗菌药物的调配方法。方法以溶剂品种、初溶溶剂体积、振荡时间为影响因素,以调配液中不溶性微粒数量为考察指标,采用L_(9)(3^(4))正交试验法优选3种静脉用难溶性抗菌药物的调配方法。结果溶剂种类(灭菌注射用水、0.9%氯化钠注射液、5%葡萄糖注射液)对3种药品不溶性微粒数量均无显著影响(P<0.05)。哌拉西林钠他唑巴坦钠的优选调配方法为采用22.5 mL溶剂预溶后,置振荡器上振荡120 s,稀释,调配;头孢呋辛钠的优选调配方法为采用12.5 mL溶剂预溶后,置振荡器上振荡40 s,稀释,调配;头孢哌酮钠舒巴坦钠的优选调配方法为采用10.0 mL溶剂预溶后,置振荡器上振荡40 s,稀释,调配。以0.9%氯化钠注射液为溶剂,按优选方法分别调配哌拉西林钠他唑巴坦钠、头孢呋辛钠、头孢哌酮钠舒巴坦钠,3种药品的不溶性微粒数量均显著减少(P>0.05)。结论优选的调配方法稳定、可行,可保障静脉输液质量。Objective To optimize the preparation methods of three intravenous insoluble antibacterial drugs(piperacillin tazobactam sodium,cefuroxime sodium,and cefoperazone sodium and sulbactam sodium).Methods Taking the variety of solvent,volume of initial solvent,and shock time as influencing factors,and with the number of insoluble particles in the preparation solution as the inspection index,the L_(9)(3^(4)) orthogonal test was used to optimize the preparation methods of three intravenous insoluble antibacterial drugs.Results The types of solvents(Sterile Water for Injection,0.9% Sodium Chloride Injection,and 5%Glucose Injection) had no significant effect on the number of insoluble particles of the three drugs(P<0.05).The optimal preparation method for piperacillin sodium and tazobactam sodium was as follows:it was pre-dissolved in 22.5 mL of solvent,put on the oscillator,and shaken for 120 s before dilution and preparation.The optimal preparation method for cefuroxime sodium was as follows:it was pre-dissolved in 12.5 mL of solvent,put on the oscillator,and shaken for 40 s before dilution and preparation.The optimal preparation method for cefoperazone sodium and sulbactam sodium was as follows:it was pre-dissolved in 10.0 mL of solvent,put on the oscillator,and shaken for 40 s before dilution and preparation.With 0.9%Sodium Chloride Injection as the solvent,piperacillin sodium and tazobactam sodium,cefuroxime sodium,and cefoperazone sodium and sulbactam sodium were prepared according to the optimal method,and the number of insoluble particles of the three drugs significantly reduced(P>0.05).Conclusion The optimal preparation methods are stable and feasible,which can ensure the quality of intravenous infusion.

关 键 词：不溶性微粒 抗菌药物 L_(9)(3^(4))正交试验法 静脉用药调配中心 

分 类 号：R95[医药卫生—药学] R978.1