骨化三醇联合氯沙坦治疗糖尿病肾病的临床研究  

Clinical Study of Calcitriol Combined with Losartan in Treatment of Diabetes Nephropathy

作　　者：莫志宁 韩美如 殷礼群 MO Zhining;HAN Meiru;YIN Liqun(Dongguan City Qingxi Hospital,Dongguan,Guangdong 523066)

机构地区：[1]东莞市清溪医院,广东东莞523066

出　　处：《智慧健康》2023年第19期117-120,共4页Smart Healthcare

基　　金：东莞市社会发展科技项目《骨化三醇联合氯沙坦治疗糖尿病肾病的临床研究》(项目编号:20211800902112)。

摘　　要：目的探讨对糖尿病肾病患者采用骨化三醇联合氯沙坦治疗临床疗效。方法选取2021年3月-2022年6月东莞市清溪医院肾脏内科收治的60例糖尿病肾病患者作为本次研究对象,根据治疗方法将患者随机分为观察组与对照组,各30例。对照组采用氯沙坦治疗,观察组采用骨化三醇联合氯沙坦治疗。对比两组患者临床疗效、肾功能指标、血糖水平与炎症因子水平。结果治疗后,观察组临床总有效率显著高于对照组,差异有统计学意义(P<0.05);观察组肾功能指标、血糖水平及炎症因子水平均低于对照组,差异有统计学意义(P<0.05)。结论骨化三醇联合氯沙坦治疗糖尿病肾病取得了显著的临床疗效,不仅能提高患者肾功能,改善蛋白尿,还能减轻机体炎性反应,值得推广。Objective To investigate clinical effect of calcitriol combined with losartan in treatment of diabetes nephropathy.Methods The paper chose 60 patients with diabetes nephropathy admitted to nephrology department of Dongguan Qingxi Hospital from March 2021 to June 2022 as study subjects,and divided them into observation group and control group randomly according to treatment method,with 30 cases in each group.Control group was treated with losartan,observation group with calcitriol combined with losartan.Clinical effect,renal function indicators,blood glucose levels and inflammatory factor levels were compared between two groups.Results After treatment,total clinical effective rate of observation group was 96.67%,significantly higher than 66.67%of control group,(P<0.05).Renal function indicators,blood glucose levels and inflammatory factor levels in observation group were lower than control group(P<0.05).Conclusion Calcitriol combined with losartan can achieve significant clinical effect in treatment of diabetes nephropathy,can improve renal function of patients,proteinuria,reduce inflammatory reaction of the body,which is worthy of promotion.

关 键 词：骨化三醇联 氯沙坦 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌] R692[医药卫生—内科学]