重度子痫前期应用血塞通胶囊的临床疗效观察及作用机制探析  

Clinical Effects and Mechanism of Treating Severe Preeclampsia with Xuesaitong Capsule

作　　者：胡瑜 杨风 祝欣欣 孙学文 马静蕊 周晨 HU Yu;YANG Feng;ZHU Xin-xin;SUN Xue-wen;MA Jing-rui;ZHOU Chen(Department of Obstetrics and Gynecology,Dengzhou Central Hospital,Dengzhou 474150,China;Department of Obstetrics and Gynecology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]河南省邓州市中心医院妇产科,邓州474150 [2]郑州大学第一附属医院妇产科,郑州450000

出　　处：《中国合理用药探索》2023年第10期104-109,共6页Chinese Journal of Rational Drug Use

基　　金：河南省卫生和计划生育委员会资助项目(201808466)。

摘　　要：目的:探讨血塞通胶囊治疗重度子痫前期的临床疗效及其作用机制。方法:选取2020年2月~2022年3月某院收治的重度子痫前期患者260例,采用随机数字表法分为对照组和观察组,每组130例。对照组在常规治疗基础上给予低剂量的低分子肝素钙注射液,观察组在对照组治疗基础上加用血塞通胶囊。比较两组临床疗效、凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)]、血脂代谢指标[总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)]、氧化应激指标[超氧化物歧化酶(SOD)、丙二醛(MDA)]与炎症因子[肿瘤坏死因子-α(TNF-α)]、血管内皮因子[内皮素-1(ET-1)、一氧化氮(NO)]水平变化。结果:观察组的临床治疗总有效率(96.15%)高于对照组(88.46%,P<0.05)。治疗后,与对照组比较,观察组PT、APTT、TT均延长(P<0.05);观察组TC、TG、LDL-C均较低;观察组SOD水平高于对照组(P<0.05),MDA、TNF-α水平低于对照组(P<0.05);观察组血清ET-1水平低于对照组(P<0.05),NO水平高于对照组(P<0.05)。结论:重度子痫前期患者在应用低剂量低分子肝素的基础上加用血塞通可有效改善凝血功能和血脂代谢,调节氧化应激指标、炎症因子和血管内皮因子水平。Objective:To investigate the effects of Xuesaitong combined with low-dose low-molecularweight heparin in patients with severe preeclampsia.Methods:A total of 260 patients with severe preeclampsia admitted to a hospital from February 2020 to March 2022 were selected.The patients were randomly divided into a control group and a observation group,with 130 cases in each group,using a random number table method.The control group received low-dose low-molecular-weight heparin injections in addition to the routine treatment,while the observation group received Xuesaitong capsule addition to the control group treatment.The coagulation function(thromboplastin time) of the two groups was compared.Additionally,the changes in plasma lipid metabolism(total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C)),oxidative stress(superoxide dismutase(SOD),malondialdehyde(MDA)),tumor necrosis factor-α(TNF-α) and vascular endothelial factor-1(ET-1)itric oxide(NO)) were observed.Results:The overall effective rate of clinical treatment in the observation group(96.15%) was higher than that in the control group(88.46%,P<0.05).APTT,PT and TT in the observation group were significantly longer than those in the control group(P<0.05).TC,TG and LDL-C in the observation group were significantly lower than those in the control group(P<0.05).The levels of SOD in the observation group were significantly higher than those in the control group(P<0.05),while the levels of MDA and TNF-α were significantly lower(P<0.05).The serum ET-1 level was significantly lower(P<0.05) but the NO level was significantly higher(P<0.05) in the observation group.Conclusion:In patients with severe preeclampsia,the addition of Xuesaitong to low-dose low-molecular-weight heparincan effectively improve the coagulation function and blood lipid metabolism,as well as regulate the levels of oxidative stress factors,inflammatory factors and vascular endothelial factors.

关 键 词：重度子痫前期 血塞通胶囊 低分子肝素 凝血功能 血管内皮因子 

分 类 号：R714.245[医药卫生—妇产科学]