炎症介质谱联合降钙素原在尿源性脓毒血症中的诊断价值  

Diagnostic value of inflammatory mediators profile combined with procalcitonin in urogenic sepsis

作　　者：伍学成 李远伟[1] 袁武雄[1] 王建松[1] 石泳中[1] 卢强[1] 李卓[1] 陈佳[1] 刘哲[1] 滕伊漓 高智勇[1] Wu Xuecheng;Li Yuanwei;Yuan Wuxiong;WangJiansong;Shi Yongzhong;Lu Qiang;Li Zhuo;Chen Jia;Liu Zhe;Teng Yili;Gao Zhiyong(Hunan Provincial People's Hospital(the First Afiliated Hospital of Hunan Normal University),Changsha 410005,China)

机构地区：[1]湖南省人民医院(湖南师范大学附属第一医院)泌尿外科,长沙410005

出　　处：《中华腔镜泌尿外科杂志(电子版)》2023年第5期476-480,共5页Chinese Journal of Endourology(Electronic Edition)

基　　金：湖南省卫生健康委项目(B202304056125)。

摘　　要：目的评估炎症介质谱联合降钙素原在输尿管结石并发尿源性脓毒血症中的诊断价值。方法收集湖南省人民医院2017年6月至2022年6月行炎症因子试剂盒检测的160例输尿管结石患者临床资料,研究组66例(输尿管结石术后发生尿源性脓毒血症患者),对照组94例(输尿管结石术后未发生尿源性脓毒血症患者)。分析两组患者的临床资料、围手术期生化指标的差异,采用多因素Logistic回归分析引起尿源性脓毒血症的相关危险因素。结果研究组术前血浆中IL-4、IL-6、IL-10、TFN-α、IFN-γ、CRP、PCT指标明显高于对照组,两组之间差异有统计学意义(P<0.05);研究组术后血浆中炎症介质谱、CRP、PCT指标均高于对照组,两组之间差异有统计学意义(P<0.05)。多因素Logistic回归分析显示:术前PCT和IL-6升高是输尿管结石术后尿源性脓毒血症的危险因素。结论IL-6和PCT升高是输尿管结石术后发生尿源性脓毒血症的重要预测指标。Objective To assess the diagnostic value of inflammatory mediator profile combined with procalcitonin in the perioperative period of ureteric stones complicated by urogenic sepsis.Methods Clinical data of 160 patients with ureteral stones who underwent inflammatory cytokine kit testing admitted to Hunan Provincial People's Hospital between June 2017 and June 2022 were collected,66 patients in the study group(patients with ureteral stones who developed urogenic sepsis after surgery)and 94 patients in the control group(patients who did not develop urogenic sepsis after ureteral stones).The differences in clinical data and perioperative biochemical indexes between the two groups were analyzed,and the risk factors causing urogenic sepsis were analyzed by multifactorial logistic regression.Results The preoperative plasma indices of IL-4,IL-6,IL-10,TFN-α,IFN-γ,CRP,and PCT in the study group were significantly higher than those in the control group,with significant differences between the two groups(P<0.05);the postoperative plasma indices of inflammatory mediator profile,CRP,and PCT in the study group were higher than those in the control group,with significant differences between the two groups(P<0.05).Multi-factor logistic regression analysis showed that elevated preoperative PCT and IL-6 were risk factors for ureteric sepsis after ureterolithotomy.Conclusions IL-6 and PCT were significant predictors of urogenic sepsis that would occur fer ureteral stone surgery.

关 键 词：炎症介质谱 降钙素原 尿源性脓毒血症 输尿管结石 

分 类 号：R699.4[医药卫生—泌尿科学]