腹主动脉钙化患者肾结石成分特点及危险因素分析  

Analysis of the composition characteristics and risk factors of kidney stones in patients with abdominal arterial calcification

作　　者：徐哲 罗杰 吴强 李忠 王晓伟 郑硕 郝晓东 王照[1] Xu Zhe;Luo Jie;Wu Qiang;Li Zhong;Wang Xiaowei;Zheng Shuo;Hao Xiaodong;Wang Zhao(Department of Urology,the First Hospital of Hebei Medical University,Shijiazhuang 050000,China;Department of Urology the Second People's Hospital of Nejiang City,Sichuan 641100,China)

机构地区：[1]河北医科大学第一医院泌尿外科,石家庄050000 [2]内江市第二人民医院泌尿外科,四川641100

出　　处：《中华腔镜泌尿外科杂志(电子版)》2023年第5期481-485,共5页Chinese Journal of Endourology(Electronic Edition)

基　　金：河北省卫生健康委科研基金项目(20160708);河北省中医药管理局科研计划项目(2020165)。

摘　　要：目的探讨腹主动脉钙化(AAC)患者肾结石成分特点及其形成的危险因素。方法选择2021年1月至2022年2月河北医科大学第一医院90例AAC合并肾结石患者为观察组,随机抽取同期体检中心AAC未合并肾结石患者为对照组(88例)。分析观察组结石成分特点,比较两组一般临床资料,采用Logistic回归分析AAC患者形成肾结石的独立危险因素。结果观察组结石成分主要为草酸钙结石22例(24.44%)和草酸钙+碳酸磷灰石30例(33.33%)。单因素分析显示观察组男性(P=0.033)合并高血压(P<0.001)合并糖尿病(P=0.004)有吸烟史(P=0.039)患者人数明显多于对照组;血胆固醇(P=0.038)低密度脂蛋白胆固醇(LDL-C)(P=0.023)血尿酸(P=0.006)明显高于对照组,高密度脂蛋白胆固醇(HDL-C)明显低于对照组(P=0.001)。Logistic回归分析显示:合并高血压、低HDL-C、高LDL-C及高血尿酸是AAC患者肾结石形成的独立危险因素(OR>1,P<0.05)。结论AAC患者肾结石成分主要以草酸钙结石、草酸钙+碳酸磷灰石为主,高血压、低HDL-C、高LDL-C、高血尿酸均是AAC患者形成肾结石的独立危险因素,临床应早期筛查其潜在危险因素并采取相关措施。Objective To investigate the composition characteristics and risk factors of renal stone in patients with abdominal aortic calcification(AAC).Methods From January 2021 to February 2022,90 patients with AAC complicated with kidney stones in the First Hospital of Hebei Medical University were selected as the observation group,randomly selected patients with AAC without nephrolithiasis in the physical examination center during the same period as the control group(88 cases).The characteristics of stone composition in the observation group were analyzed,and the clinical data and biochemical indexes of the two groups were compared.Binary Logistic regression was used to analyze the independent risk factors of renal stone formation in patients with AAC.Results The stones in the observation group were mainly composed of calcium oxalate stones in 22 cases(24.44%)and calcium oxalate+carbonated apatite in 30 cases(33.33%).Univariate analysis showed that in the observation group,the proportion of patients with male(P=0.033),hypertension(P<0.001),diabetes(P=0.004),smoking history(P=0.039),TC(P=0.038),LDL-C(P=0.023),blood uric acid(P=0.006)were significantly higher than those in the control group,and HDL-C was significantly lower than that in the control group(P-0.001).Logistic regression analysis showed that hypertension,low HDL-C,high LDL-C and hyperuricemia were independent risk factors for renal stone formation in patients with AAC(OR>1,P<0.05).Conclusions The main components of kidney stones in patients with AAC are calcium oxalate stones,calcium oxalate+carbonated apatite.Hypertension,low HDL-C,high LDL-C,and hyperuricemia are independent risk factors for the formation of kidney stones in patients with AAC.Potential risk factors should be screened early in clinical practice and relevant measures should be taken.

关 键 词：腹主动脉钙化 肾结石 结石成分 危险因素 

分 类 号：R692.4[医药卫生—泌尿科学]