抗痛风药托匹司他研究现状与进展  

Research Status and Progress of Anti-gout Drug Topiroxostat

作　　者：尹璐 邓晨希 朱杰 李正文 尹自秋 雷蕊蕊 刘崇怡 Yin Lu;Deng Chenxi;Zhu Jie;Li Zhengwen;Yin Ziqiu;Lei Ruirui;Liu Chongyi(Sichuan Industrial Institute of Antibiotics,College of Pharmacy,Chengdu University,Sichuan,610106)

机构地区：[1]成都大学药学院四川抗菌素工业研究所,四川610106

出　　处：《当代化工研究》2023年第20期20-22,共3页Modern Chemical Research

基　　金：四川省科技厅重点研发项目“抗痛风新药托匹司他合成新工艺研究”(项目编号:2020YFS0065);中国国家留学基金委(CSC)2022年西部地区人才培养特别项目留金项〔2022〕20号(项目编号:202208515062);成都大学2022年大学生创新创业项目“多廿烷醇的制备”。

摘　　要：作为一种高效的特异性黄嘌呤氧化酶抑制剂,托匹司他具有选择性高,特异性强等优点,应用十分广泛,极具临床价值。其在临床治疗痛风和高尿酸血症疗效好,副作用少,且不影响嘌呤及嘧啶的代谢合成。本文从抗痛风药物的合成方法对托匹司他近几年的研究现状进行总结和讨论,进一步了解托匹司他的结构与性质的关系,以期为托匹司他合成工艺的改进提供帮助。Topiroxostat is a specific xanthine oxidase inhibitor with high selectivity,wide application and high clinical value.It is effective in the treatment of gout and hyperuricemia with few side effects,and does not affect the metabolism of purine and pyrimidine.In this paper,we has summarized the research actuality of topiroxostat in recent years and discussed from the classification,clinical application and synthesis methods of antigout drugs,so as to further understand the relationship between the structure and properties of topiroxostat,in order to provide more information for the improvement of synthesis process.

关 键 词：托匹司他 痛风 高尿酸血症 合成工艺 

分 类 号：TQ463[化学工程—制药化工]