血清SIRT6、FBLN1水平与腹膜透析患者腹主动脉钙化的关系  

Relationships between serum SIRT6 and FBLN1 levels and abdominal aortic calcification in peritoneal dialysis patients

作　　者：王林琳 王晴岚 林玉洁 李剑恺 WANG Linlin;WANG Qinglan;LIN Yujie;LI Jiankai(Hemodialysis Room,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 210000,China)

机构地区：[1]上海中医药大学附属曙光医院血透室,上海210000

出　　处：《山东医药》2023年第31期10-14,共5页Shandong Medical Journal

基　　金：上海市卫生健康委员会卫生行业临床研究专项(20194Y0077)。

摘　　要：目的探讨患者血清沉默信息调节因子6(SIRT6)、腓骨蛋白1(FBLN1)水平与腹膜透析(PD)患者腹主动脉钙化(AAC)的关系。方法选取132例PD患者为PD组,同期另选取46名健康体检者为对照组。采用酶联免疫吸附法检测两组血清SIRT6、FBLN1;收集PD患者病历资料;根据AAC积分将PD患者分为AAC组53例、非AAC组79例。用Spearman相关法分析AAC患者血清SIRT6、FBLN1水平与AAC积分的相关性;用多因素Logistic回归分析PD患者AAC的影响因素;用受试者工作特征(ROC)曲线分析血清SIRT6、FBLN1水平对PD患者AAC的评估价值。结果PD组血清SIRT6水平低于对照组,FBLN1水平高于对照组(P均<0.05)。Spearman相关法分析显示,AAC患者AAC积分与血清SIRT6水平呈负相关,与FBLN1水平呈正相关(r_(s)分别为-0.793、0.796,P均<0.05)。透析龄延长和全段甲状旁腺素、FBLN1升高为PD患者AAC的独立危险因素,SIRT6升高为独立保护因素(P均<0.05)。ROC曲线分析显示,血清SIRT6、FBLN1水平单独与联合评估PD患者AAC的曲线下面积分别为0.781、0.780、0.866,二者联合评估的曲线下面积高于单独指标评估(P均<0.05)。结论血清SIRT6水平降低、FBLN1水平升高与PD患者AAC密切相关,血清SIRT6联合FBLN1评估PD患者AAC的价值较高。Objective To investigate the relationships between serum silent information regulator transcript 6(SIRT6)and fibulin 1(FBLN1)levels and abdominal aortic calcification(AAC)in peritoneal dialysis(PD)patients.Methods Totally 132 patients with PD were selected as the PD group,and another 46 healthy medical examiners were selected as the control group during the same period.The enzyme-linked immunosorbent assay was used to detect serum SIRT6 and FBLN1 in the two groups;the medical records of PD patients were collected;and the PD patients were divided into the AAC group of 53 cases and non-AAC group of 79 cases according to the AAC score.Spearman's correlation method was used to analyze the correlation between serum SIRT6 and FBLN1 levels and AAC scores in patients with AAC;multifactorial Logistic regression was used to analyze the influencing factors of AAC in patients with PD;and the value of serum SIRT6 and FBLN1 levels in assessing AAC in PD patients was analyzed by the receiver operating characteristic(ROC)curve.Results Serum SIRT6 level was lower and FBLN1 level was higher in the PD group than in the control group(both P<0.05).Spearman's correlation analysis showed that the AAC score of AAC patients was negatively correlated with the serum SIRT6 level and was positively correlated with the FBLN1 level(r_(s)=-0.793 and 0.796,both P<0.05).Prolonged dialysis age and elevated whole parathyroid hormone and FBLN1 were independent risk factors for AAC in PD patients,and elevated SIRT6 was an independent protective factor(all P<0.05).ROC curve analysis showed that the area under the curve of serum SIRT6 and FBLN1 levels individually and in combination in assessing AAC of PD patients were 0.781,0.780,and 0.866,respectively,and the area under the curve of them combined in evaluation was higher than that of either alone(all P<0.05).Conclusion Serum SIRT6 level decreases and FBLN1 level increases in PD patients,which are closely related to AAC,and serum SIRT6 combined with FBLN1 is of high value in assessing AAC in PD patien

关 键 词：腹主动脉钙化 腹膜透析 沉默信息调节因子6 腓骨蛋白1 

分 类 号：R459.5[医药卫生—治疗学]