基于“病甚取输”理论针刺联合中药治疗慢性自发性荨麻疹临床研究  

Study on the Clinical Efficacy for Acupuncture Combined with Traditional Chinese Medicine in the treatment of Chronic Spontaneous Urticaria Based on the Theory of“Taking Shupoints when the Disease is Aggravated”

作　　者：秦悦思[1] 汪丽君 李天星 杨峥茹 蒋莎莉 何艳[3] 苏红[1] QIN Yuesi;WANG Lijun;LI Tianxing(Chengdu Integrated Traditional Chinese and Western Medicine Hospital,Chengdu Sichuan 610041,China;Chengdu University of Traditional Chinese Medicine,Chengdu Sichuan 610075,China)

机构地区：[1]成都市中西医结合医院,四川成都610041 [2]成都中医药大学,四川成都610075 [3]四川大学华西医院龙泉医院,四川成都610100

出　　处：《四川中医》2023年第9期186-191,共6页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省科技厅自然科学基金青年基金(编号:23NSFSC5347);成都市卫健委医学科研课题(编号:2020004)。

摘　　要：目的:基于“病甚取输”理论,观察针刺与发病时间对应的“输穴”联合中药治疗慢性自发性荨麻疹(CSU)的临床疗效。方法:采用多中心、随机、对照的研究方法,将99例CSU患者分为A组(中药组)、B组(基础取穴+中药组)和C组(基础取穴+输穴+中药组),每组各33例,治疗周期均为4周。对三组患者进行7日荨麻疹的活动度评分(UAS7)、瘙痒模拟视觉评分(VAS)、慢性荨麻疹生活质量问卷(CU-Q2oL),比较各组的临床疗效。结果:治疗后,A组、B组、C组总有效率分别为63.33%(19/30)、80.00%(24/30)、90.32%(28/31),组间差异具有统计学意义(P<0.05)。C组在UAS7评分、瘙痒VAS评分、CU-Q2oL评分改善方面均优于A组与B组;治疗后,C组患者血清P物质(SP)、白介素31(IL-31)水平降低显著优于A组与B组(P<0.05)。结论:针刺与发病时间对应的“输穴”联合中药治疗CSU,能显著缓解患者瘙痒症状,改善患者生活质量,可能与下调血清SP、IL-31,调节神经-炎症-免疫相关,该疗法临床疗效确切。Objective:To observe the clinical effect of acupuncture combined with traditional Chinese medicine on chronic spontaneous urticaria(CSU)based on the theory of“taking shupoints when the disease is aggravated”.Methods:Using a multicenter,randomized,controlled study method,99patients with CSU were divided into Group A(Traditional Chinese Medicine group),Group B(basic acupuncture points+Traditional Chinese Medicine group),Groups C(basic acupuncture points+shupoints+Traditional Chinese Medicine group),and 33cases in each group,with a 4-week treatment period.Urticaria activity score over 7days(UAS7),pruritus Visual Analogue Scale(VAS),and a chronic urticaria quality of life questionnaire(CUQ2oL)were performed in the three groups to compare the clinical efficacy of each group.Results:After the treatment,the total effective rates of the three groups were 63.33%(19/30,group A),80.00%(24/30,group B),and 90.32%(28/31,group C),respectively.And the difference was statistically significant(P<0.05).Group C showed better improvement in UAS7scores,pruritus VAS scores,and CU-Q2oL scores than Group A and Group B.After treatment,the levels of serum substance P(SP)and interleukin-31(IL-31)levels were reduced in Group C patients(P<0.05).Conclusion:The treatment of CSU by acupuncture at“shupoints”related to the time of onset,combined with traditional Chinese medicine,could significantly relieve patients'pruritus symptoms,improve their quality of life,which may be related to down-regulate serum SP and IL-31,regulating nerve-inflammation-immunity.The clinical efficacy of this therapy is confirmed.

关 键 词：慢性自发性荨麻疹 病甚取输 针药结合 

分 类 号：R246.7[医药卫生—针灸推拿学]