经皮冠状动脉介入术后宽胸气雾剂雾化吸入治疗急性心肌梗死的效果与作用机制  

Curative effect and action mechanism of Kuanxiong Aerosol inhalation on acute myocardial infarction after percutaneous coronary intervention

作　　者：张欣欣[1] 贾轶男 陶杰[1] 许巧玲[1] 刘欣[1] 陈亚伟[1] ZHANG Xinxin;JIA Yi’nan;TAO Jie;XU Qiaoling;LIU Xin;CHEN Yawei(The Fourth Department of Cardiovascular Medicine,Baoding First Central Hospital,Baoding 071000,China)

机构地区：[1]保定市第一中心医院心血管内四科,保定071000

出　　处：《西北药学杂志》2023年第6期189-193,共5页Northwest Pharmaceutical Journal

基　　金：保定市科技计划项目(编号:2241ZF069)。

摘　　要：目的探讨经皮冠状动脉介入(percutaneous coronary intervention,PCI)术后宽胸气雾剂雾化吸入治疗急性心肌梗死(acute myocardial infarction,AMI)的效果及作用机制。方法选取106例AMI行PCI手术治疗的患者,随机分为观察组和对照组,每组53例。对照组给予常规西医治疗,观察组在对照组治疗的基础上加用宽胸气雾剂,比较2组的临床疗效、中医证候积分、心电图疗效、心功能、冠状动脉血流速度、血管内皮功能和不良反应发生情况。结果治疗后,观察组的临床治疗有效率(96.23%)高于对照组(83.02%),P<0.05;2组心电图比较差异无统计学意义(P>0.05);观察组治疗后胸闷、胸痛、气短心悸、神倦乏力、自汗、懒言和面色暗淡评分均低于对照组(P<0.05);观察组左室射血分数(left ventricular ejection fraction,LVEF)、冠状动脉血流速度储备(coronary flow velocity reserve,CFVR)和收缩期血流峰值速度(peak systolic velocity,PSV)水平均高于对照组(P<0.05);观察组校正TIMI帧计数(corrected timi frame counted,CTFC)水平低于对照组(P<0.05);观察组血清内皮素(endothelin-1,ET-1)、环腺苷酸(cyclic adenosine monophosphate,cAMP)水平低于对照组,环鸟甘酸(cyclic guanosine monophosphate,cGMP)、一氧化氮水平高于对照组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论PCI术后宽胸气雾剂雾化吸入治疗AMI可有效减轻患者的临床症状,提升心功能,提高冠状动脉血流灌注水平,改善血管内皮功能,效果显著且安全性高。Objective To investigate the curative effect and action mechanism of Kuanxiong Aerosol inhalation on acute myocardial infarction(AMI)after percutaneous coronary intervention(PCI).Methods A total of 106 patients with AMI undergoing PCI were enrolled and randomly divided into observation group(53 cases)and control group(53 cases).The control group was given routine western medicines,while the observation group was additionally given Kuanxiong Aerosol inhalation.The clinical curative effect,the scores of traditional Chinese medicine(TCM)syndromes,the curative effect of electrocardiogram,cardiac function,coronary blood flow velocity,vascular endothelial function and the occurrence of adverse reactions were compared between different groups.Results After treatment,the response rate of clinical treatment was higher in observation group than in control group(96.23%vs 83.02%)(P<0.05).There was no significant difference in electrocardiogram between the 2groups(P>0.05).After treatment,the scores of TCM syndromes(chest tightness,chest pain,shortness of breath and palpitation,mental fatigue,spontaneous sweating,laziness to speak,and pale complexion)were lower in observation group than in control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF),coronary flow velocity reserve(CFVR)and peak systolic velocity(PSV)in the observation group were higher than those in the control group,the level of corrected TIMI frame count(CTFC)in the observation group was lower than that in the control group(P<0.05).The levels of serum endothelin(ET-1)and cyclic adenylate(cAMP)in the observation group were lower than those in the control group,while the levels of cyclic guanosine monophosphate(cGMP)and nitric oxide were higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the 2groups(P>0.05).Conclusion Kuanxiong Aerosol inhalation can effectively relieve clinical symptoms,improve cardiac function,coronary blood flow perfusion and vascular endothel

关 键 词：宽胸气雾剂 急性心肌梗死 经皮冠状动脉介入治疗 作用机制 

分 类 号：R972[医药卫生—药品]