数据挖掘视角下的大枣临床经验用药探讨  

Discussion on the clinical experience of jujube application from the perspective of data mining

作　　者：朱禹 岳仁宋[1] 黄菊 王华玲 张明旭 ZHU Yu;YUE Rensong;HUANG Ju;WANG Hualing;ZHANG Mingxu(Department of Endocrinology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Department of Oncology,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;School of Ophthalmology,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学附属医院内分泌科,成都610075 [2]成都中医药大学附属医院肿瘤科,成都610075 [3]成都中医药大学眼科学院,成都610075

出　　处：《西北药学杂志》2023年第6期219-226,共8页Northwest Pharmaceutical Journal

基　　金：四川省中医药管理局科学技术研究专项课题(编号:2021ZD011);四川省名中医工作室项目(编号:202112)。

摘　　要：目的基于中医传承计算平台(V3.0),探索岳仁宋教授处方中使用大枣的临床用药规律及其配伍规律。方法收集整理了岳仁宋教授门诊在专科疾病治疗中使用了大枣药物的有效病案5239个,包含处方5239首,规范录入中医传承计算平台(V3.0)后,构建含大枣的复方数据库,将大枣分为低剂量(≤30 g)、中剂量(30 g<剂量≤60 g)和高剂量(>60 g),据此对复方进行分类,对大枣不同剂量下的复方用药规律进行挖掘和整理。结果共纳入含大枣的复方5239首,中药448味。大枣低剂量时,多合用和解剂。大枣中、高剂量时,多联合使用苦寒清热药黄连。所有剂量情况下,除大枣本身的温性、甘味频次最多外,四气中均以寒性最多,五味中均以苦味最多,归经中频次前3分别为脾、肺和胃(低剂量)与脾、胃和肺(中剂量)以及脾、胃和肺(高剂量)。药物功效统计中,所有剂量下除补虚类最多外,其次为清热类。设定置信度为0.9,支持度为30%,选出了排名前6的核心组合,药物关联规则及聚类分析得到了不同的核心药物组合。结论岳仁宋教授在治疗中大枣剂量使用灵活,在大枣低剂量时处方善用和法,中、高剂量时处方治本以助脾散精,治标用于抑制食欲亢进,使用中、高剂量大枣多同时配伍苦寒清热药物,与患者多出现火热亢盛症状、需标本兼治有关。Objective Based on the Traditional Chinese Medicine Inheritance Computing Platform(V3.0,TCM-ICP),to explore the medication and compatibility experience of jujube in Professor Yue Rensong's prescriptions.Methods 5239 effective medical records of Professor Yue Rensong who used jujube in the treatment of specialized diseases were collected and sorted out,including 5239 prescriptions.After applying the TCM-ICP,we constructed a compound database containing jujube,and divided jujube into low dose(≤30 g),middle dose(30-60 g)and high dose(60 g).According to this,the compound prescription was classified,and the law of compound medication of jujube at different doses was excavated and sorted out.Results A total of 5239 compound prescriptions containing jujube and 448 Chinese medicines were included.When the dosage of jujube was low,harmonizing prescription were used more frequently.In the middle and high doses of jujube,Coptis chinensis,a bitter cold and heat-clearing drug,was often used in combination.In all doses,except for the warm nature and sweetness of jujube itself,the cold nature was the most prevalent in four nactures,and the bitterness was the most prevalent in five flavors.The top three of meridian tropism are spleen,lung and stomach(low dose),spleen,stomach and lung(middle dose)and spleen,stomach and lung(high dose)respectively.The highest number of drugs was found at all doses except for the deficiency tonic category,followed by the heat-clearing category.A confidence level of 0.9 and support of 30%were set to select the top 6 core combinations,and drug association rules and cluster analysis yielded different core drug combinations.Conclusion Professor Yue Rensong used jujube flexibly in the treatment.When the dose of jujube was low,the prescription and method was based on the idea of harmonization.When the dose was medium or high,the prescription was mainly used to help the spleen and disperse essence,and mainly used to inhibit hyperactivity of appetite.When the dose was medium or high,related to the fact t

关 键 词：大枣 岳仁宋 中医传承计算平台 用药规律 

分 类 号：R969.3[医药卫生—药理学]