生物医学微波热声成像  

Biomedical microwave-induced thermoacoustic imaging

作　　者：王雨 张慧敏[1,2,3,4] 覃欢 Wang Yu;Zhang Hui-Min;Qin Huan(Key Laboratory of Laser Life Science&Institute of Laser Life Science,Ministry of Education,South China Normal University,Guangzhou 510631,China;Guangdong Provincial Key Laboratory of Laser Life Science,South China Normal University,Guangzhou 510631,China;Guangzhou Key Laboratory of Spectral Analysis and Functional Probes,South China Normal University,Guangzhou 510631,China;College of Biophotonics,South China Normal University,Guangzhou 510631,China)

机构地区：[1]华南师范大学,激光生命科学教育部重点实验室,广州510631 [2]华南师范大学,广东省激光生命科学重点实验室,广州510631 [3]华南师范大学,广州市光谱分析与功能探针重点实验室,广州510631 [4]华南师范大学生物光子学研究院,广州510631

出　　处：《物理学报》2023年第20期286-297,共12页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:62075066);广东省基础与应用基础研究基金(批准号:2023A1515010824);广州市科技计划(批准号:202201010718)资助的课题.

摘　　要：微波热声成像是一种以生物组织电特性差异为原理基础的多物理场耦合成像方法.其采用脉冲微波作为激发源,通过热弹性效应产生的超声波呈递深层生物组织的结构与功能信息,融合了微波成像高对比度和超声成像高分辨率的优点.目前已在无损脑结构成像、乳腺肿瘤筛查、人体关节炎成像、肝脂肪含量检测等方面展现出了广阔的医学应用前景,有望成为新的物理医学影像方法.本文对微波热声成像技术的物理原理、系统装置以及近来的代表性研究进展进行了系统性的介绍,并分析探讨了微波热声成像技术值得关注的发展方向以及面临的挑战.Microwave thermoacoustic imaging(MTAI)is an exciting imaging technique rooted from the underlying principle of exploiting the distinct electrical properties of biological tissues.By using short-pulsed microwaves as a stimulation source and their interaction with the human body,MTAI has paved the way for revolutionary advancements in medical imaging.When microwaves are absorbed by polar molecules and ions within the tissues,an ingenious thermoelastic effect gives rise to ultrasound waves.These ultrasound waves,brimming with invaluable pathological and physiological insights,propagate outward,carrying the essence of the composition and functionality of biological tissue.Through a meticulous collection of ultrasound signals from all directions surrounding the tissue,it becomes possible to reconstruct intricate internal structures and visualize the tissue's functional dynamics.The MTAI excels in non-invasiveness,capable of delving several centimeters beneath the surface with a microscopic resolution on the order of micrometers.The magic lies in converting microwave energy into ultrasound waves,entering into the hidden depths of tissues without causing harm.This groundbreaking imaging modality unlocks a realm of possibilities for acquiring profound insights into the intricate structures and functionality of deep-seated tissues.Furthermore,the inherent polarization characteristics of microwaves empower MTAI to capture additional dimensions of information,unraveling the intricate polarization properties and illuminating a richer understanding of the tissue's complexity.The great potential of MTAI extends far and wide within the medicine field.It has made remarkable achievements in noninvasive imaging of brain structures,screening breast tumors,visualizing human arthritis,and detecting liver fat content.These accomplishments have laid a solid foundation,firmly establishing MTAI as a trailblazing medical imaging technique.The present study offers a comprehensive and in-depth exploration of the physical principles underpin

关 键 词：微波热声成像 生物组织电特性 微波源 脑成像技术 

分 类 号：R318[医药卫生—生物医学工程] TP391.41[医药卫生—基础医学]