偏振光声成像技术的研究与发展  

Research and development of polarized photoacoustic imaging technology

作　　者：刘劼 陈伟 杨秋琳 穆根 高昊 申滔 杨思华 张振辉 Liu Jie;Chen Wei;Yang Qiu-Lin;Mu Gen;Gao Hao;Shen Tao;Yang Si-Hua;Zhang Zhen-Hui(School of Information Optoelectronics Technology,South China Normal University,Guangzhou 510006,China;Key Laboratory of Laser Life Sciences,Ministry of Education,Institute of Biological Photonics,South China Normal University,Guangzhou 510631,China)

机构地区：[1]华南师范大学信息光电子科技学院,广州510006 [2]华南师范大学生物光子学研究院,激光生命科学教育部重点实验室,广州510631

出　　处：《物理学报》2023年第20期314-332,共19页Acta Physica Sinica

基　　金：国家自然科学基金(批准号:12304483,62335007);广东省自然科学基金(批准号:2022A1515010548);广州市科技计划(批准号:2019050001,202206010094)资助的课题.

摘　　要：生命体是一个高度有序化的结合体,细胞和组织的基本生物过程本质上受生物分子构象和排列的控制,其中生物分子的排列有序度、取向、螺旋和折叠等特征与生物组织的生理功能密切相关.偏振成像可以获取生命体或材料的微观排列结构,取向和手性等构象信息,在材料学检测,生物影像领域得到了广泛的应用,但其成像深度和解析偏振信息等方面存在困难.光声成像以电磁波为激发源,以超声为载体传递信息,成为一种结合光学高对比度和超声深穿透性的无损成像方式,利用扩散光子激发目标并检测由此产生的声响应可以打破光学扩散极限的限制.近年来一种偏振光声成像技术作为偏振光学成像的补充,在保证成像深度的同时可以获取介质的三维偏振信息,为组织的偏振测量提供了一种有效而直接的策略,预示着在生物成像和材料检测两方面的巨大潜力.本文总结了偏振光声成像技术的发展,首先阐明了偏振光声成像的物理原理和技术方法,随后从生物组织成像和纳米材料检测两个应用领域展开介绍了偏振光声显微成像、偏振光声计算层析成像和偏振光声纳米材料分子成像的相关研究进展,并且简要论述了偏振光在组织中传播时因颗粒尺寸、密度、排列等因素产生的退偏情况,最后展望了偏振光声成像的应用前景.Life is a highly ordered combination,and the basic biological processes of cells and tissues are essentially controlled by the structural order of biomolecular assembly,in which the conformational characteristics of biomolecule arrangement,orientation,helix,and folding are closely related to the physiological functions of biological tissues.In the skin,muscle,and nerve tissues of living animals,for instance,fibrous proteins,collagen,nerve fibers,and DNA frequently exhibit molecular spatial conformation properties such as particular alignment or helical structure,and such tissues have distinct optical polarization responses.The fundamental structural foundation for tissues to carry out certain activities is provided by molecular conformational characteristics.Early illness diagnosis will be aided by the accurate detection and efficient revelation of molecular conformational characteristics and their changes.The microscopic organization,structure,orientation,chirality,and other structural details of living things or materials can be obtained by using polarization imaging.The analysis of the imaging depth and polarization data is challenging,despite its widespread usage in the fields of material detection and biological imaging.Photoacoustic imaging preserves both the great contrast of optical imaging and the deep penetration of ultrasonic imaging by using light as an excitation source and ultrasound as the carrier for information transmission.While keeping the benefits of non-invasiveness,it is capable of highresolution imaging,deep penetration,and functional imaging.A polarized photoacoustic imaging technology has recently been developed to complement polarization optical imaging and allow the collection of threedimensional polarization data from deeper layers of the medium.This provides a straightforward and efficient method of measuring the polarimetry of tissues,suggesting substantial promise for both biological imaging and substance detection.The evolution of polarized photoacoustic imaging technology is outli

关 键 词：各向异性 分子取向 手性 偏振光声成像 

分 类 号：R318[医药卫生—生物医学工程] O436.3[医药卫生—基础医学] TP391.41[机械工程—光学工程]