Nomogram prediction model called“ADPLCP”for predictinglinezolid-associated thrombocytopenia in elderly individuals  

作　　者：Yanxin Liu Jiang Wang Tingting Liu Kun Xiao Peng Yan Xiangqun Fang Lixin Xie 

机构地区：[1]Department of Pulmonary and Critical Care Medicine,The Second Medical Center,National Clinical Research Center for Geriatric Diseases,Chinese PLA GeneralHospital,Beijing 100853,China [2]Centre of Pulmonary and Critical Care Medicine,Chinese PLA General Hospital,Beijing 100853,China

出　　处：《Journal of Intensive Medicine》2023年第3期268-274,共7页重症医学（英文）

摘　　要：Background:Linezolid-associated thrombocytopenia(LAT)leads to drug withdrawal associated with a poor prognosis.Some risk factors for LAT have been identified;however,the sample size of previous studies was small,data from elderly individuals are limited,and a simple risk score scale was not established to predict LAT at anearly stage,making it difficult to identify and intervene in LAT at an early stage.Methods:In this single-center retrospective case-control study,we enrolled elderly patients treated with linezolidin the intensive care unit from January 2015 to December 2020.All the data of enrolled patients,includingdemographic information and laboratory findings at baseline,were collected.We analyzed the incidence andrisk factors for LAT and established a nomogram risk prediction model for LAT in the elderly population.Results:A total of 428 elderly patients were enrolled,and the incidence of LAT was 35.5%(152/428).Age≥80 years old(OR=1.980;95%CI:1.179–3.325;P=0.010),duration of linezolid≥10 days(OR=1.100;95%CI:1.050–1.152;P<0.0001),platelet count at baseline(100–149×10^(9)/L vs.≥200×10^(9)/L,OR=8.205,95%CI:4.419–15.232,P<0.0001;150–199×10^(9)/L vs.≥200×10^(9)/L,OR=3.067,95%CI:1.676–5.612,P<0.001),leukocytecount at baseline≥16×10^(9)/L(OR=2.580;95%CI:1.523–4.373;P<0.0001),creatinine clearance<50 mL/min(OR=2.323;95%CI:1.388–3.890;P=0.001),and total protein<60 g/L(OR=1.741;95%CI:1.039–2.919;P=0.035)were associated with LAT.The nomogram prediction model called“ADPLCP”(age,duration,platelet,leukocyte,creatinine clearance,protein)was established based on logistic regression.The area under the curve(AUC)of ADPLCP was 0.802(95%CI:0.748–0.856;P<0.0001),with 78.9%sensitivity and 69.2%specificity(cut-off was 108).Risk stratification for LAT was performed based on“ADPLCP.”Total points of<100 were defined as low risk,and the possibility of LAT was<32.0%.Total points of 100–150 were defined as medium risk,and the possibility of LAT was 32.0–67.5%.A total point>150 was defined

关 键 词：Linezolid-associated thrombocytopenia NOMOGRAM Risk prediction model Elderly individuals 

分 类 号：R95[医药卫生—药学]